Epidemiology of breast cancer in women

Steven S. Coughlin, Yasmin Cypel

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Epidemiologic studies have contributed importantly to current knowledge of environmental and genetic risk factors for breast cancer. Worldwide, breast cancer is an important cause of human suffering and premature mortality among women. In the United States, breast cancer accounts for more cancer deaths in women than any site other than lung cancer. A variety of risk factors for breast cancer have been well-established by epidemiologic studies including race, ethnicity, family history of cancer, and genetic traits, as well as modifiable exposures such as increased alcohol consumption, physical inactivity, exogenous hormones, and certain female reproductive factors. Younger age at menarche, parity, and older age at first full-term pregnancy may influence breast cancer risk through long-term effects on sex hormone levels or by other biological mechanisms. Recent studies have suggested that triple negative breast cancers may have a distinct etiology. Genetic variants and mutations in genes that code for proteins having a role in DNA repair pathways and the homologous recombination of DNA double stranded breaks (BRCA1, BRCA2, XRCC2, XRCC3, ATM, CHEK2, PALB2, RAD51), have been implicated in some cases of breast cancer.

Original languageEnglish (US)
Title of host publicationBreast Cancer Metastasis and Drug Resistance
Subtitle of host publicationProgress and Prospects
PublisherSpringer New York
Pages19-34
Number of pages16
Volume9781461456476
ISBN (Electronic)9781461456476
ISBN (Print)1461456460, 9781461456469
DOIs
Publication statusPublished - Aug 1 2013
Externally publishedYes

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Keywords

  • Anthropometric factors
  • Environmental exposures
  • Family history
  • Gene mutations
  • Genetic factors
  • Genetic polymorphisms
  • Incidence
  • International trends
  • Ionizing radiation exposure
  • Mammographic breast density
  • Race
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Coughlin, S. S., & Cypel, Y. (2013). Epidemiology of breast cancer in women. In Breast Cancer Metastasis and Drug Resistance: Progress and Prospects (Vol. 9781461456476, pp. 19-34). Springer New York. https://doi.org/10.1007/978-1-4614-5647-6_2