Epidemiology of Breast Cancer in Women

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Epidemiologic studies have contributed importantly to current knowledge of environmental and genetic risk factors for breast cancer. Worldwide, breast cancer is an important cause of human suffering and premature mortality among women. In the United States, breast cancer accounts for more cancer deaths in women than any site other than lung cancer. A variety of risk factors for breast cancer have been well-established by epidemiologic studies including race, ethnicity, family history of cancer, and genetic traits, as well as modifiable exposures such as increased alcohol consumption, physical inactivity, exogenous hormones, and certain female reproductive factors. Younger age at menarche, parity, and older age at first full-term pregnancy may influence breast cancer risk through long-term effects on sex hormone levels or by other biological mechanisms. Recent studies have suggested that triple negative breast cancers may have a distinct etiology. Genetic variants and mutations in genes that code for proteins having a role in DNA repair pathways and the homologous recombination of DNA double stranded breaks (APEX1, BRCA1, BRCA2, XRCC2, XRCC3, ATM, CHEK2, PALB2, RAD51, XPD), have been implicated in some cases of breast cancer.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages9-29
Number of pages21
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1152
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Epidemiology
Breast Neoplasms
DNA
Gonadal Steroid Hormones
Automatic teller machines
Epidemiologic Studies
Repair
Genes
Alcohols
Hormones
Triple Negative Breast Neoplasms
Recombinational DNA Repair
Menarche
Premature Mortality
Double-Stranded DNA Breaks
Parity
Psychological Stress
DNA Repair
Alcohol Drinking
Lung Neoplasms

Keywords

  • Alcohol
  • Breast cancer
  • Diet
  • Epidemiology
  • Genetics
  • Physical activity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Coughlin, S. S. (2019). Epidemiology of Breast Cancer in Women. In Advances in Experimental Medicine and Biology (pp. 9-29). (Advances in Experimental Medicine and Biology; Vol. 1152). Springer New York LLC. https://doi.org/10.1007/978-3-030-20301-6_2

Epidemiology of Breast Cancer in Women. / Coughlin, Steven S.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 9-29 (Advances in Experimental Medicine and Biology; Vol. 1152).

Research output: Chapter in Book/Report/Conference proceedingChapter

Coughlin, SS 2019, Epidemiology of Breast Cancer in Women. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1152, Springer New York LLC, pp. 9-29. https://doi.org/10.1007/978-3-030-20301-6_2
Coughlin SS. Epidemiology of Breast Cancer in Women. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2019. p. 9-29. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-030-20301-6_2
Coughlin, Steven S. / Epidemiology of Breast Cancer in Women. Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. pp. 9-29 (Advances in Experimental Medicine and Biology).
@inbook{04cff686761548738388dbcaf94aaebb,
title = "Epidemiology of Breast Cancer in Women",
abstract = "Epidemiologic studies have contributed importantly to current knowledge of environmental and genetic risk factors for breast cancer. Worldwide, breast cancer is an important cause of human suffering and premature mortality among women. In the United States, breast cancer accounts for more cancer deaths in women than any site other than lung cancer. A variety of risk factors for breast cancer have been well-established by epidemiologic studies including race, ethnicity, family history of cancer, and genetic traits, as well as modifiable exposures such as increased alcohol consumption, physical inactivity, exogenous hormones, and certain female reproductive factors. Younger age at menarche, parity, and older age at first full-term pregnancy may influence breast cancer risk through long-term effects on sex hormone levels or by other biological mechanisms. Recent studies have suggested that triple negative breast cancers may have a distinct etiology. Genetic variants and mutations in genes that code for proteins having a role in DNA repair pathways and the homologous recombination of DNA double stranded breaks (APEX1, BRCA1, BRCA2, XRCC2, XRCC3, ATM, CHEK2, PALB2, RAD51, XPD), have been implicated in some cases of breast cancer.",
keywords = "Alcohol, Breast cancer, Diet, Epidemiology, Genetics, Physical activity",
author = "Coughlin, {Steven S.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/978-3-030-20301-6_2",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "9--29",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - CHAP

T1 - Epidemiology of Breast Cancer in Women

AU - Coughlin, Steven S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Epidemiologic studies have contributed importantly to current knowledge of environmental and genetic risk factors for breast cancer. Worldwide, breast cancer is an important cause of human suffering and premature mortality among women. In the United States, breast cancer accounts for more cancer deaths in women than any site other than lung cancer. A variety of risk factors for breast cancer have been well-established by epidemiologic studies including race, ethnicity, family history of cancer, and genetic traits, as well as modifiable exposures such as increased alcohol consumption, physical inactivity, exogenous hormones, and certain female reproductive factors. Younger age at menarche, parity, and older age at first full-term pregnancy may influence breast cancer risk through long-term effects on sex hormone levels or by other biological mechanisms. Recent studies have suggested that triple negative breast cancers may have a distinct etiology. Genetic variants and mutations in genes that code for proteins having a role in DNA repair pathways and the homologous recombination of DNA double stranded breaks (APEX1, BRCA1, BRCA2, XRCC2, XRCC3, ATM, CHEK2, PALB2, RAD51, XPD), have been implicated in some cases of breast cancer.

AB - Epidemiologic studies have contributed importantly to current knowledge of environmental and genetic risk factors for breast cancer. Worldwide, breast cancer is an important cause of human suffering and premature mortality among women. In the United States, breast cancer accounts for more cancer deaths in women than any site other than lung cancer. A variety of risk factors for breast cancer have been well-established by epidemiologic studies including race, ethnicity, family history of cancer, and genetic traits, as well as modifiable exposures such as increased alcohol consumption, physical inactivity, exogenous hormones, and certain female reproductive factors. Younger age at menarche, parity, and older age at first full-term pregnancy may influence breast cancer risk through long-term effects on sex hormone levels or by other biological mechanisms. Recent studies have suggested that triple negative breast cancers may have a distinct etiology. Genetic variants and mutations in genes that code for proteins having a role in DNA repair pathways and the homologous recombination of DNA double stranded breaks (APEX1, BRCA1, BRCA2, XRCC2, XRCC3, ATM, CHEK2, PALB2, RAD51, XPD), have been implicated in some cases of breast cancer.

KW - Alcohol

KW - Breast cancer

KW - Diet

KW - Epidemiology

KW - Genetics

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=85071740397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071740397&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-20301-6_2

DO - 10.1007/978-3-030-20301-6_2

M3 - Chapter

C2 - 31456177

AN - SCOPUS:85071740397

T3 - Advances in Experimental Medicine and Biology

SP - 9

EP - 29

BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -