Epidemiology of nosocomial acquisition of Candida lusitaniae

V. Sanchez, Jose Antonio Vazquez, D. Barth-Jones, L. Dembry, J. D. Sobel, M. J. Zervos

Research output: Contribution to journalComment/debate

70 Citations (Scopus)

Abstract

Candida species are important nosocomial pathogens; however, little is known about the epidemiology of Candida lusitaniae, an organism frequently resistant to amphotericin B. We evaluated 98 patients admitted to the bone marrow transplant and medical intensive care units of a tertiary-care hospital. Each patient with C. lusitaniae was matched with control patients. Restriction fragment analysis of DNA was used to determine strain relatedness. Seven patients (7.1%) with C. lusitaniae were identified; five acquired C. lusitaniae after admission to the study unit. All isolates were susceptible to amphotericin B. There were no differences between patients and controls with regard to duration of stay in the study unit, antibiotic administration, antifungal therapy, immunosuppressive therapy, catheter use, or underlying disease. Temporal and geographic clustering of five patients with identical strains occurred. No common source was identified. Restriction fragment analysis revealed a total of eight strains, and five patients shared one strain type. These results demonstrate exogenous acquisition of C. lusitaniae. The mechanism of acquisition is probably indirect contact transmission between patients.

Original languageEnglish (US)
Pages (from-to)3005-3008
Number of pages4
JournalJournal of clinical microbiology
Volume30
Issue number11
StatePublished - Jan 1 1992

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Candida
Epidemiology
Amphotericin B
Antifungal Agents
Tertiary Healthcare
Immunosuppressive Agents
Tertiary Care Centers
Intensive Care Units
Cluster Analysis
Catheters
Bone Marrow
Transplants
DNA
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Sanchez, V., Vazquez, J. A., Barth-Jones, D., Dembry, L., Sobel, J. D., & Zervos, M. J. (1992). Epidemiology of nosocomial acquisition of Candida lusitaniae. Journal of clinical microbiology, 30(11), 3005-3008.

Epidemiology of nosocomial acquisition of Candida lusitaniae. / Sanchez, V.; Vazquez, Jose Antonio; Barth-Jones, D.; Dembry, L.; Sobel, J. D.; Zervos, M. J.

In: Journal of clinical microbiology, Vol. 30, No. 11, 01.01.1992, p. 3005-3008.

Research output: Contribution to journalComment/debate

Sanchez, V, Vazquez, JA, Barth-Jones, D, Dembry, L, Sobel, JD & Zervos, MJ 1992, 'Epidemiology of nosocomial acquisition of Candida lusitaniae', Journal of clinical microbiology, vol. 30, no. 11, pp. 3005-3008.
Sanchez V, Vazquez JA, Barth-Jones D, Dembry L, Sobel JD, Zervos MJ. Epidemiology of nosocomial acquisition of Candida lusitaniae. Journal of clinical microbiology. 1992 Jan 1;30(11):3005-3008.
Sanchez, V. ; Vazquez, Jose Antonio ; Barth-Jones, D. ; Dembry, L. ; Sobel, J. D. ; Zervos, M. J. / Epidemiology of nosocomial acquisition of Candida lusitaniae. In: Journal of clinical microbiology. 1992 ; Vol. 30, No. 11. pp. 3005-3008.
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