TY - JOUR
T1 - Epigenetic Regulation of Cardiac Neural Crest Cells
AU - Yan, Shun
AU - Lu, Jin
AU - Jiao, Kai
N1 - Funding Information:
Research in the authors’ laboratory is supported by R56 (HL130711), R01 (HL095783), AHA (17GRNT33410623), and CHARGE Scientific Research grants (awarded to KJ).
Publisher Copyright:
© Copyright © 2021 Yan, Lu and Jiao.
PY - 2021/4/21
Y1 - 2021/4/21
N2 - The cardiac neural crest cells (cNCCs) is a transient, migratory cell population that contribute to the formation of major arteries and the septa and valves of the heart. Abnormal development of cNCCs leads to a spectrum of congenital heart defects that mainly affect the outflow region of the hearts. Signaling molecules and transcription factors are the best studied regulatory events controlling cNCC development. In recent years, however, accumulated evidence supports that epigenetic regulation also plays an important role in cNCC development. Here, we summarize the functions of epigenetic regulators during cNCC development as well as cNCC related cardiovascular defects. These factors include ATP-dependent chromatin remodeling factors, histone modifiers and DNA methylation modulators. In many cases, mutations in the genes encoding these factors are known to cause inborn heart diseases. A better understanding of epigenetic regulators, their activities and their roles during heart development will ultimately contribute to the development of new clinical applications for patients with congenital heart disease.
AB - The cardiac neural crest cells (cNCCs) is a transient, migratory cell population that contribute to the formation of major arteries and the septa and valves of the heart. Abnormal development of cNCCs leads to a spectrum of congenital heart defects that mainly affect the outflow region of the hearts. Signaling molecules and transcription factors are the best studied regulatory events controlling cNCC development. In recent years, however, accumulated evidence supports that epigenetic regulation also plays an important role in cNCC development. Here, we summarize the functions of epigenetic regulators during cNCC development as well as cNCC related cardiovascular defects. These factors include ATP-dependent chromatin remodeling factors, histone modifiers and DNA methylation modulators. In many cases, mutations in the genes encoding these factors are known to cause inborn heart diseases. A better understanding of epigenetic regulators, their activities and their roles during heart development will ultimately contribute to the development of new clinical applications for patients with congenital heart disease.
KW - cardiac neural crest cell
KW - cardiovascular development
KW - congenital heart diasease
KW - epigenetic regulation
KW - heart development
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U2 - 10.3389/fcell.2021.678954
DO - 10.3389/fcell.2021.678954
M3 - Review article
AN - SCOPUS:85105207663
SN - 2296-634X
VL - 9
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 678954
ER -