Epigenetic states are orchestrated by several converging and reinforcing signals, including DNA methylation, histone modifications and non-coding RNAs. Growing evidence indicates that acquired epigenetic abnormalities participate with genetic alterations to cause cancer. In this review we describe recent advances in the field of cancer epigenomics and microRNAs (miRNAs) with special emphasis on renal cancer. We discuss whether epigenetic changes are the cause or consequence of cancer initiation and the use of epigenetic biomarkers and miRNAs for cancer diagnosis or prognosis. Finally we address the potential of epigenetic based anti-cancer therapeutic strategies.
- Renal cancer
ASJC Scopus subject areas