Epigenetics and MicroRNAs in renal cancer

Shahana Majid, Sharanjot Saini, Guoren Deng, Rajvir Dahiya

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epigenetic states are orchestrated by several converging and reinforcing signals, including DNA methylation, histone modifications and non-coding RNAs. Growing evidence indicates that acquired epigenetic abnormalities participate with genetic alterations to cause cancer. In this review we describe recent advances in the field of cancer epigenomics and microRNAs (miRNAs) with special emphasis on renal cancer. We discuss whether epigenetic changes are the cause or consequence of cancer initiation and the use of epigenetic biomarkers and miRNAs for cancer diagnosis or prognosis. Finally we address the potential of epigenetic based anti-cancer therapeutic strategies.

Original languageEnglish (US)
Title of host publicationEpigenetics and Cancer
PublisherSpringer Netherlands
Pages63-84
Number of pages22
ISBN (Electronic)9789400766129
ISBN (Print)9400766114, 9789400766112
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

Keywords

  • Epigenetics
  • MicroRNA
  • Renal cancer

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Majid, S., Saini, S., Deng, G., & Dahiya, R. (2013). Epigenetics and MicroRNAs in renal cancer. In Epigenetics and Cancer (pp. 63-84). Springer Netherlands. https://doi.org/10.1007/978-94-007-6612-9_4