Epigenomics of Hypertension

Mingyu Liang, Allen W. Cowley, David L. Mattson, Theodore A. Kotchen, Yong Liu

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Multiple genes and pathways are involved in the pathogenesis of hypertension. Epigenomic studies of hypertension are beginning to emerge and hold great promise of providing novel insights into the mechanisms underlying hypertension. Epigenetic marks or mediators including DNA methylation, histone modifications, and noncoding RNA can be studied at a genome or near-genome scale using epigenomic approaches. At the single gene level, several studies have identified changes in epigenetic modifications in genes expressed in the kidney that correlate with the development of hypertension. Systematic analysis and integration of epigenetic marks at the genome-wide scale, demonstration of cellular and physiological roles of specific epigenetic modifications, and investigation of inheritance are among the major challenges and opportunities for future epigenomic and epigenetic studies of hypertension.

Original languageEnglish (US)
Pages (from-to)392-399
Number of pages8
JournalSeminars in Nephrology
Volume33
Issue number4
DOIs
StatePublished - Jul 2013

Keywords

  • Blood pressure
  • DNA methylation
  • Epigenetics
  • Histone modification
  • Kidney

ASJC Scopus subject areas

  • Nephrology

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    Liang, M., Cowley, A. W., Mattson, D. L., Kotchen, T. A., & Liu, Y. (2013). Epigenomics of Hypertension. Seminars in Nephrology, 33(4), 392-399. https://doi.org/10.1016/j.semnephrol.2013.05.011