Epitope selection and development of peptide based vaccines to treat cancer

Esteban Celis; Alessandro Sette; Howard M. Grey

doi:10.1016/1044-579X(95)90002-0

Epitope selection and development of peptide based vaccines to treat cancer

Esteban Celis, Alessandro Sette, Howard M. Grey

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Cytotoxic T lymphocytes recognize peptides that associate with class I major histocompatibility complex molecules. Since cytotoxic T cells have the capacity to recognize and destroy tumor cells, identification of epitopes recognized by these cells in tumor-associated antigens would allow the production of compounds for the treatment of cancer. Here we review some of the approaches being explored to identify tumor-associated antigens and to develop peptide-based vaccines that induce cytotoxic T lymphocytes against specific tumors.

Original language	English (US)
Pages (from-to)	329-336
Number of pages	8
Journal	Seminars in Cancer Biology
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/1044-579X(95)90002-0
State	Published - Jan 1 1995
Externally published	Yes

Keywords

Cytotoxic T-cell epitopes
Epitopes
HLA-binding peptides
Peptide vaccine
Tumor-associated antigens
Tumor-associated CTL

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/1044-579X(95)90002-0

Cite this

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title = "Epitope selection and development of peptide based vaccines to treat cancer",

abstract = "Cytotoxic T lymphocytes recognize peptides that associate with class I major histocompatibility complex molecules. Since cytotoxic T cells have the capacity to recognize and destroy tumor cells, identification of epitopes recognized by these cells in tumor-associated antigens would allow the production of compounds for the treatment of cancer. Here we review some of the approaches being explored to identify tumor-associated antigens and to develop peptide-based vaccines that induce cytotoxic T lymphocytes against specific tumors.",

keywords = "Cytotoxic T-cell epitopes, Epitopes, HLA-binding peptides, Peptide vaccine, Tumor-associated antigens, Tumor-associated CTL",

author = "Esteban Celis and Alessandro Sette and Grey, {Howard M.}",

year = "1995",

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doi = "10.1016/1044-579X(95)90002-0",

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T1 - Epitope selection and development of peptide based vaccines to treat cancer

AU - Celis, Esteban

AU - Sette, Alessandro

AU - Grey, Howard M.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Cytotoxic T lymphocytes recognize peptides that associate with class I major histocompatibility complex molecules. Since cytotoxic T cells have the capacity to recognize and destroy tumor cells, identification of epitopes recognized by these cells in tumor-associated antigens would allow the production of compounds for the treatment of cancer. Here we review some of the approaches being explored to identify tumor-associated antigens and to develop peptide-based vaccines that induce cytotoxic T lymphocytes against specific tumors.

AB - Cytotoxic T lymphocytes recognize peptides that associate with class I major histocompatibility complex molecules. Since cytotoxic T cells have the capacity to recognize and destroy tumor cells, identification of epitopes recognized by these cells in tumor-associated antigens would allow the production of compounds for the treatment of cancer. Here we review some of the approaches being explored to identify tumor-associated antigens and to develop peptide-based vaccines that induce cytotoxic T lymphocytes against specific tumors.

KW - Cytotoxic T-cell epitopes

KW - Epitopes

KW - HLA-binding peptides

KW - Peptide vaccine

KW - Tumor-associated antigens

KW - Tumor-associated CTL

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AN - SCOPUS:0029421213

SN - 1044-579X

VL - 6

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EP - 336

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

IS - 6

ER -

Epitope selection and development of peptide based vaccines to treat cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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