Epitope selection and development of peptide based vaccines to treat cancer

Esteban Celis, Alessandro Sette, Howard M. Grey

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Cytotoxic T lymphocytes recognize peptides that associate with class I major histocompatibility complex molecules. Since cytotoxic T cells have the capacity to recognize and destroy tumor cells, identification of epitopes recognized by these cells in tumor-associated antigens would allow the production of compounds for the treatment of cancer. Here we review some of the approaches being explored to identify tumor-associated antigens and to develop peptide-based vaccines that induce cytotoxic T lymphocytes against specific tumors.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalSeminars in Cancer Biology
Volume6
Issue number6
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Cytotoxic T-cell epitopes
  • Epitopes
  • HLA-binding peptides
  • Peptide vaccine
  • Tumor-associated antigens
  • Tumor-associated CTL

ASJC Scopus subject areas

  • Cancer Research

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