Epstein-barr virus-induced lymphoma in a cardiac transplant recipient

J. Stephen Dummer, Linda M. Bound, Gurmukh Singh, R. Wayne Atchison, Silloo B. Kapadia, Monto HO

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A monoclonal diffuse histiocytic lymphoma developed during the course of a serologically documented primary Epstein-Barr virus infection in a 22-year-old cardiac transplant recipient taking cyclosporine and prednisone. Throat washings revealed the virus at tumor presentation, and the tumor was shown to contain EpsteinBarr nuclear antigen-positive cells and the viral genome. Prolonged inversion of the T cell helper/suppressor ratio was demonstrated. A brief course of acyclovir appeared to halt viral shedding in the throat but had no apparent effect on the tumor.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalThe American Journal of Medicine
Volume77
Issue number1
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Pharynx
Human Herpesvirus 4
Lymphoma
Virus Shedding
Oncogenic Viruses
Nuclear Antigens
Epstein-Barr Virus Infections
Acyclovir
Lymphoma, Large B-Cell, Diffuse
Viral Genome
Helper-Inducer T-Lymphocytes
Prednisone
Cyclosporine
Neoplasms
Transplant Recipients

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Epstein-barr virus-induced lymphoma in a cardiac transplant recipient. / Dummer, J. Stephen; Bound, Linda M.; Singh, Gurmukh; Atchison, R. Wayne; Kapadia, Silloo B.; HO, Monto.

In: The American Journal of Medicine, Vol. 77, No. 1, 01.01.1984, p. 179-184.

Research output: Contribution to journalArticle

Dummer, J. Stephen ; Bound, Linda M. ; Singh, Gurmukh ; Atchison, R. Wayne ; Kapadia, Silloo B. ; HO, Monto. / Epstein-barr virus-induced lymphoma in a cardiac transplant recipient. In: The American Journal of Medicine. 1984 ; Vol. 77, No. 1. pp. 179-184.
@article{635767d0a7b947f789c18137842e5be0,
title = "Epstein-barr virus-induced lymphoma in a cardiac transplant recipient",
abstract = "A monoclonal diffuse histiocytic lymphoma developed during the course of a serologically documented primary Epstein-Barr virus infection in a 22-year-old cardiac transplant recipient taking cyclosporine and prednisone. Throat washings revealed the virus at tumor presentation, and the tumor was shown to contain EpsteinBarr nuclear antigen-positive cells and the viral genome. Prolonged inversion of the T cell helper/suppressor ratio was demonstrated. A brief course of acyclovir appeared to halt viral shedding in the throat but had no apparent effect on the tumor.",
author = "Dummer, {J. Stephen} and Bound, {Linda M.} and Gurmukh Singh and Atchison, {R. Wayne} and Kapadia, {Silloo B.} and Monto HO",
year = "1984",
month = "1",
day = "1",
doi = "10.1016/0002-9343(84)90458-3",
language = "English (US)",
volume = "77",
pages = "179--184",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Epstein-barr virus-induced lymphoma in a cardiac transplant recipient

AU - Dummer, J. Stephen

AU - Bound, Linda M.

AU - Singh, Gurmukh

AU - Atchison, R. Wayne

AU - Kapadia, Silloo B.

AU - HO, Monto

PY - 1984/1/1

Y1 - 1984/1/1

N2 - A monoclonal diffuse histiocytic lymphoma developed during the course of a serologically documented primary Epstein-Barr virus infection in a 22-year-old cardiac transplant recipient taking cyclosporine and prednisone. Throat washings revealed the virus at tumor presentation, and the tumor was shown to contain EpsteinBarr nuclear antigen-positive cells and the viral genome. Prolonged inversion of the T cell helper/suppressor ratio was demonstrated. A brief course of acyclovir appeared to halt viral shedding in the throat but had no apparent effect on the tumor.

AB - A monoclonal diffuse histiocytic lymphoma developed during the course of a serologically documented primary Epstein-Barr virus infection in a 22-year-old cardiac transplant recipient taking cyclosporine and prednisone. Throat washings revealed the virus at tumor presentation, and the tumor was shown to contain EpsteinBarr nuclear antigen-positive cells and the viral genome. Prolonged inversion of the T cell helper/suppressor ratio was demonstrated. A brief course of acyclovir appeared to halt viral shedding in the throat but had no apparent effect on the tumor.

UR - http://www.scopus.com/inward/record.url?scp=0021278814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021278814&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(84)90458-3

DO - 10.1016/0002-9343(84)90458-3

M3 - Article

VL - 77

SP - 179

EP - 184

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 1

ER -