Epstein-barr virus-induced lymphoma in a cardiac transplant recipient

J. Stephen Dummer, Linda M. Bound, Gurmukh Singh, R. Wayne Atchison, Silloo B. Kapadia, Monto HO

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A monoclonal diffuse histiocytic lymphoma developed during the course of a serologically documented primary Epstein-Barr virus infection in a 22-year-old cardiac transplant recipient taking cyclosporine and prednisone. Throat washings revealed the virus at tumor presentation, and the tumor was shown to contain EpsteinBarr nuclear antigen-positive cells and the viral genome. Prolonged inversion of the T cell helper/suppressor ratio was demonstrated. A brief course of acyclovir appeared to halt viral shedding in the throat but had no apparent effect on the tumor.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalThe American Journal of Medicine
Volume77
Issue number1
DOIs
StatePublished - Jul 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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