Erbb3-mediated regulation of bergmann glia proliferation in cerebellar lamination

Anupama Sathyamurthy, Dong Min Yin, Arnab Barik, Chengyong Shen, Jonathan C. Bean, Dwight Figueiredo, Jin Xiong She, Wen Cheng Xiong, Lin Mei

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cortical lamination is crucial for the assembly of cerebellar circuitry. In this process, granule neurons (GNs) migrate along Bergmann glia (BG), which are specialized astroglial cells, from the external granule layer to the internal granule layer. However, the molecular mechanisms underlying BG development are not well understood. Here, we show that GFAP::Cre;Erbb3F/F mice, which lack Erbb3 in both radial glia and neurons, exhibit impairments in balance and motor coordination. Cerebellar lamination is aberrant, with misplaced Purkinje neurons and GN clusters. These phenotypes were not observed in Math1::CreERT2;Erbb3F/F mice, where the Erbb3 gene was deleted in GNs, suggesting involvement of non-neuronal Erbb3 in cerebellar lamination. Mechanistic studies indicate that ERBB3 is crucial for the proliferation of BG, which are required for GN migration. These observations identify a crucial role for ERBB3 in cerebellar lamination and reveal a novel mechanism that regulates BG development.

Original languageEnglish (US)
Pages (from-to)522-532
Number of pages11
JournalDevelopment (Cambridge)
Volume142
Issue number3
DOIs
StatePublished - Feb 1 2015

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Neuroglia
Neurons
Purkinje Cells
Phenotype
Genes

Keywords

  • Bergmann glia
  • Cerebellum
  • ERBB3
  • Mouse

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

Sathyamurthy, A., Yin, D. M., Barik, A., Shen, C., Bean, J. C., Figueiredo, D., ... Mei, L. (2015). Erbb3-mediated regulation of bergmann glia proliferation in cerebellar lamination. Development (Cambridge), 142(3), 522-532. https://doi.org/10.1242/dev.115931

Erbb3-mediated regulation of bergmann glia proliferation in cerebellar lamination. / Sathyamurthy, Anupama; Yin, Dong Min; Barik, Arnab; Shen, Chengyong; Bean, Jonathan C.; Figueiredo, Dwight; She, Jin Xiong; Xiong, Wen Cheng; Mei, Lin.

In: Development (Cambridge), Vol. 142, No. 3, 01.02.2015, p. 522-532.

Research output: Contribution to journalArticle

Sathyamurthy, A, Yin, DM, Barik, A, Shen, C, Bean, JC, Figueiredo, D, She, JX, Xiong, WC & Mei, L 2015, 'Erbb3-mediated regulation of bergmann glia proliferation in cerebellar lamination', Development (Cambridge), vol. 142, no. 3, pp. 522-532. https://doi.org/10.1242/dev.115931
Sathyamurthy A, Yin DM, Barik A, Shen C, Bean JC, Figueiredo D et al. Erbb3-mediated regulation of bergmann glia proliferation in cerebellar lamination. Development (Cambridge). 2015 Feb 1;142(3):522-532. https://doi.org/10.1242/dev.115931
Sathyamurthy, Anupama ; Yin, Dong Min ; Barik, Arnab ; Shen, Chengyong ; Bean, Jonathan C. ; Figueiredo, Dwight ; She, Jin Xiong ; Xiong, Wen Cheng ; Mei, Lin. / Erbb3-mediated regulation of bergmann glia proliferation in cerebellar lamination. In: Development (Cambridge). 2015 ; Vol. 142, No. 3. pp. 522-532.
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