Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons

Yanmei Tao, Yongjun Chen, Chengyong Shen, Zhengyi Luo, C. Ryan Bates, Daehoon Lee, Sylvie Marchetto, Tian Ming Gao, Jean Paul Borg, Wencheng Xiong, Lin Mei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Inhibitory neurons control the firing of glutamatergic neurons and synchronize brain activity. However, little is known about mechanisms of excitatory synapse formation in inhibitory neurons. Here we demonstrate that Erbin is specifically expressed in cortical inhibitory neurons. It localizes at excitatory synapses and regulates AMPA receptor (AMPAR) surface expression. Erbin mutation reduced mEPSCs and AMPAR currents specifically in parvalbumin (PV)-positive interneurons but not in pyramidal neurons. We found that the AMPAR auxiliary protein TARP γ-2 was specifically expressed in cortical interneurons. Erbin interacts with TARP γ-2 and is crucial for its stability. Deletion of the γ-2-interacting domain in Erbin attenuated surface AMPAR and excitatory transmission in PV-positive interneurons. Furthermore, we observed behavioral deficits in Erbin-null mice and in mice expressing an Erbin truncation mutant that is unable to interact with TARP γ-2. These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical PV-positive interneurons and may contribute to a better understanding of psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)290-299
Number of pages10
JournalNature Neuroscience
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2013

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AMPA Receptors
Interneurons
Parvalbumins
Neurons
Synapses
Pyramidal Cells
Psychiatry
TARP
Mutation
Brain
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tao, Y., Chen, Y., Shen, C., Luo, Z., Bates, C. R., Lee, D., ... Mei, L. (2013). Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons. Nature Neuroscience, 16(3), 290-299. https://doi.org/10.1038/nn.3320

Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons. / Tao, Yanmei; Chen, Yongjun; Shen, Chengyong; Luo, Zhengyi; Bates, C. Ryan; Lee, Daehoon; Marchetto, Sylvie; Gao, Tian Ming; Borg, Jean Paul; Xiong, Wencheng; Mei, Lin.

In: Nature Neuroscience, Vol. 16, No. 3, 01.03.2013, p. 290-299.

Research output: Contribution to journalArticle

Tao, Y, Chen, Y, Shen, C, Luo, Z, Bates, CR, Lee, D, Marchetto, S, Gao, TM, Borg, JP, Xiong, W & Mei, L 2013, 'Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons', Nature Neuroscience, vol. 16, no. 3, pp. 290-299. https://doi.org/10.1038/nn.3320
Tao, Yanmei ; Chen, Yongjun ; Shen, Chengyong ; Luo, Zhengyi ; Bates, C. Ryan ; Lee, Daehoon ; Marchetto, Sylvie ; Gao, Tian Ming ; Borg, Jean Paul ; Xiong, Wencheng ; Mei, Lin. / Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons. In: Nature Neuroscience. 2013 ; Vol. 16, No. 3. pp. 290-299.
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