Erythroleukemia of childhood and infancy: A report of two cases

D. Scott Day, Jack N. Gay, Jonathan S. Krauss, Hernan Sabio, K. L. Satya-Prakash, Barbara Landis Russell, William D. Wansley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Two rare de novo cases are presented of pediatric erythroleukemia (EL), AML-M6, in a four-month-old (patient A) and four-year-old (patient B) African-Americans who presented to the Medical College of Georgia from 1989 to 1995. The clinical, morphologic, immunophenotypic, and cytogenetic features of both patients are reviewed. The purpose of this study is to correlate the bone marrow morphology with the immunophenotypes and the karyotypes of the neoplastic cells. The patients were both female, presented with flu-like symptoms, and were noted to have hepatosplenomegaly on physical examination. The peripheral blood examination was significant for anemia (Hb 54 (A), 84 (B)g/L, and thrombocytopenia (86 (A), 70(B) x 109/L). The bone marrow contained 75 percent (A) and 76.8 (B) erythroblasts and showed myelodysplastic changes in the erythroid cell line. Cytochemical analysis was performed, and greater than 10 erythroblasts per 100 cells were periodic acid-Schiff positive. Immunophenotypes of the pretreatment bone marrow showed glycophorin-A, CD71, and CD11B positivity. The karyotypes of both patients contained complex (>3 per clone) cytogenetic abnormalities. Our data suggest that the initial presentation and course of disease are different in adults and children. However, once the adult form reaches the acute leukemia stage, the laboratory findings are similar to those at initial presentation in pediatric EL.

Original languageEnglish (US)
Pages (from-to)142-150
Number of pages9
JournalAnnals of Clinical and Laboratory Science
Volume27
Issue number2
StatePublished - Apr 22 1997

Fingerprint

Leukemia, Erythroblastic, Acute
Bone
Pediatrics
Erythroblasts
Bone Marrow
Glycophorin
Periodic Acid
Karyotype
Blood
Erythroid Cells
Cells
Cytogenetics
Chromosome Aberrations
Thrombocytopenia
African Americans
Physical Examination
Anemia
Leukemia
Clone Cells
Cell Line

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

Cite this

Scott Day, D., Gay, J. N., Krauss, J. S., Sabio, H., Satya-Prakash, K. L., Russell, B. L., & Wansley, W. D. (1997). Erythroleukemia of childhood and infancy: A report of two cases. Annals of Clinical and Laboratory Science, 27(2), 142-150.

Erythroleukemia of childhood and infancy : A report of two cases. / Scott Day, D.; Gay, Jack N.; Krauss, Jonathan S.; Sabio, Hernan; Satya-Prakash, K. L.; Russell, Barbara Landis; Wansley, William D.

In: Annals of Clinical and Laboratory Science, Vol. 27, No. 2, 22.04.1997, p. 142-150.

Research output: Contribution to journalArticle

Scott Day, D, Gay, JN, Krauss, JS, Sabio, H, Satya-Prakash, KL, Russell, BL & Wansley, WD 1997, 'Erythroleukemia of childhood and infancy: A report of two cases', Annals of Clinical and Laboratory Science, vol. 27, no. 2, pp. 142-150.
Scott Day D, Gay JN, Krauss JS, Sabio H, Satya-Prakash KL, Russell BL et al. Erythroleukemia of childhood and infancy: A report of two cases. Annals of Clinical and Laboratory Science. 1997 Apr 22;27(2):142-150.
Scott Day, D. ; Gay, Jack N. ; Krauss, Jonathan S. ; Sabio, Hernan ; Satya-Prakash, K. L. ; Russell, Barbara Landis ; Wansley, William D. / Erythroleukemia of childhood and infancy : A report of two cases. In: Annals of Clinical and Laboratory Science. 1997 ; Vol. 27, No. 2. pp. 142-150.
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