Establishing a biologic specimens repository for reproductive clinical trials: Technical aspects

Stephen A. Krawetz, Peter R. Casson, Michael Peter Diamond, Heping Zhang, Richard S. Legro, William D. Schlaff, Christos Coutifaris, Robert G. Brzyski, Gregory M. Christman, Nanette Santoro, Esther Eisenberg

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The individual research group or independent investigator often requires access to samples from a unique well characterized subject population. Cohorts of such samples from a well-defined comparative population are rare and limited access can impede progress. This bottleneck can be removed by accessing the samples provided by biorepositories such as the NIH/NICHD Cooperative Reproductive Medicine Network (RMN) Biorepository (detailed in the preceeding manuscript in this issue. In those cases where the individual research group or independent investigator already has access to a unique population, comparisons between well-defined groups are often sought to contextualize the data. In both cases seamless integration of data resources associated with the samples is required to ensure optimal comparisons. At the most basic level this requires standardization of sample collection and storage, as well as a de-identified data base containing demographic, clinical, and laboratory values. To facilitate such interoperability, the reagents and protocols that have been adopted by the RMN Biorepository for the collection and storage of serum, blood, saliva and sperm are described.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalSystems Biology in Reproductive Medicine
Volume57
Issue number5
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Fingerprint

Reproductive Medicine
Clinical Trials
National Institute of Child Health and Human Development (U.S.)
Research Personnel
Population
Manuscripts
Saliva
Research
Spermatozoa
Demography
Databases
Serum

Keywords

  • Biorepository
  • Protocol
  • Reproductive Medicine Network
  • Sample collection

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

Cite this

Establishing a biologic specimens repository for reproductive clinical trials : Technical aspects. / Krawetz, Stephen A.; Casson, Peter R.; Diamond, Michael Peter; Zhang, Heping; Legro, Richard S.; Schlaff, William D.; Coutifaris, Christos; Brzyski, Robert G.; Christman, Gregory M.; Santoro, Nanette; Eisenberg, Esther.

In: Systems Biology in Reproductive Medicine, Vol. 57, No. 5, 01.10.2011, p. 222-227.

Research output: Contribution to journalArticle

Krawetz, SA, Casson, PR, Diamond, MP, Zhang, H, Legro, RS, Schlaff, WD, Coutifaris, C, Brzyski, RG, Christman, GM, Santoro, N & Eisenberg, E 2011, 'Establishing a biologic specimens repository for reproductive clinical trials: Technical aspects', Systems Biology in Reproductive Medicine, vol. 57, no. 5, pp. 222-227. https://doi.org/10.3109/19396368.2011.604819
Krawetz, Stephen A. ; Casson, Peter R. ; Diamond, Michael Peter ; Zhang, Heping ; Legro, Richard S. ; Schlaff, William D. ; Coutifaris, Christos ; Brzyski, Robert G. ; Christman, Gregory M. ; Santoro, Nanette ; Eisenberg, Esther. / Establishing a biologic specimens repository for reproductive clinical trials : Technical aspects. In: Systems Biology in Reproductive Medicine. 2011 ; Vol. 57, No. 5. pp. 222-227.
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