Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism

Koichi Tanaka, Zhonglin Hao, Mihoko Kai, Hiroto Okayama

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.

Original languageEnglish (US)
Pages (from-to)5779-5790
Number of pages12
JournalEMBO Journal
Volume20
Issue number20
DOIs
StatePublished - Oct 15 2001

Fingerprint

Chromatids
Schizosaccharomyces
Yeast
Maintenance
DNA
Proteins
DNA Replication
S Phase
cohesins

Keywords

  • Cohesin
  • Eso1p
  • Fission yeast
  • Pds5p
  • Sister chromatid cohesion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism. / Tanaka, Koichi; Hao, Zhonglin; Kai, Mihoko; Okayama, Hiroto.

In: EMBO Journal, Vol. 20, No. 20, 15.10.2001, p. 5779-5790.

Research output: Contribution to journalArticle

Tanaka, Koichi ; Hao, Zhonglin ; Kai, Mihoko ; Okayama, Hiroto. / Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism. In: EMBO Journal. 2001 ; Vol. 20, No. 20. pp. 5779-5790.
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