Estrogen activity as a preventive and therapeutic target in thyroid cancer

Shilpi Rajoria, Robert Suriano, Andrea L. George, Arulkumaran Shanmugam, Casey Jussim, Edward J. Shin, Augustine L. Moscatello, Jan Geliebter, Angelo Carpi, Raj K. Tiwari

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Thyroid cancer is the most common endocrine-related cancer with increasing incidences during the last five years. Interestingly, according to the American Thyroid Association, the incidences of thyroid proliferative diseases occur four to five times more in women than in men with the risk of developing thyroid disorders being one in every eight females. Several epidemiological studies have suggested a possible correlation between incidences of thyroid malignancies and hormones but the precise contribution of estrogen in thyroid proliferative disease initiation, and progression is not well understood. This review is an attempt to define the phenotypic and genotypic modulatory effects of estrogen on thyroid proliferative diseases. The significance and relevance of expression of estrogen receptors, α and β, in normal and malignant thyroid tissues and their effects on different molecular pathways involved in growth and function of the thyroid gland are discussed. These novel findings open up areas of developing alternative therapeutic treatments and preventive approaches which employ the use of antiestrogen to treat thyroid malignancies.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalBiomedicine and Pharmacotherapy
Volume66
Issue number2
DOIs
Publication statusPublished - Mar 1 2012

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Keywords

  • Antiestrogen
  • Estrogen
  • Estrogen receptor
  • Thyroid cancer
  • Thyroid proliferative diseases

ASJC Scopus subject areas

  • Pharmacology

Cite this

Rajoria, S., Suriano, R., George, A. L., Shanmugam, A., Jussim, C., Shin, E. J., ... Tiwari, R. K. (2012). Estrogen activity as a preventive and therapeutic target in thyroid cancer. Biomedicine and Pharmacotherapy, 66(2), 151-158. https://doi.org/10.1016/j.biopha.2011.11.010