Estrogen induced metastatic modulators MMP-2 and MMP-9 are targets of 3,3′-diindolylmethane in thyroid cancer

Agriculture & Biology

• thyroid neoplasms 98%
• gelatinase B 86%
• gelatinase A 85%
• estrogens 54%
• metastasis 32%
• neoplasm cells 23%
• adhesion 22%
• hormone replacement therapy 14%
• therapeutics 13%
• disease progression 11%
• estrogenic properties 10%
• small interfering RNA 9%
• estrogen receptors 9%
• cell movement 9%
• thyroid hormones 9%
• iodine 8%
• surgery 8%
• cell proliferation 7%
• dietary supplements 7%
• Western blotting 7%
• estradiol 7%
• vegetables 6%
• neoplasms 6%
• proteinases 6%
• cell lines 6%
• incidence 6%
• phenotype 5%
• assays 4%
• methodology 2%

Medicine & Life Sciences

• 3,3'-diindolylmethane 100%
• Thyroid Neoplasms 60%
• Matrix Metalloproteinases 57%
• Estrogens 49%
• Neoplasm Metastasis 13%
• Endocrine Gland Neoplasms 11%
• Hormone Replacement Therapy 8%
• Iodine 7%
• Dietary Supplements 7%
• Thyroid Hormones 7%
• Vegetables 7%
• Cell Adhesion 7%
• Estrogen Receptors 7%
• In Vitro Techniques 6%
• Estradiol 6%
• Peptide Hydrolases 6%
• Small Interfering RNA 6%
• Thyroid Gland 6%
• Cell Movement 6%
• Disease Progression 5%
• Down-Regulation 5%
• Western Blotting 5%
• Cell Proliferation 4%
• Phenotype 4%
• Cell Line 4%
• Recurrence 4%
• Therapeutics 3%
• Incidence 3%

Chemical Compounds

• Thyroid 74%
• Estrogen 64%
• Anti-Estrogen 12%
• Antimetastatic 11%
• Thyroid Hormone 10%
• Silencing RNA 9%
• Estradiol 8%
• Iodine 6%