TY - JOUR
T1 - Estrogen-mediated mechanisms in hypertension and other cardiovascular diseases
AU - Visniauskas, Bruna
AU - Kilanowski-Doroh, Isabella
AU - Ogola, Benard O.
AU - Mcnally, Alexandra B.
AU - Horton, Alec C.
AU - Imulinde Sugi, Ariane
AU - Lindsey, Sarah H.
N1 - Funding Information:
This work was supported by the National Institutes of Health (HL133619 and AG071746 to SHL; HL155841 to BOO), the American Heart Association (829713 to BV; 827812 to IKD), and the Tulane Center of Excellence in Sex-Based Biology & Medicine.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022
Y1 - 2022
N2 - Cardiovascular disease (CVD) is the leading cause of death globally for men and women. Premenopausal women have a lower incidence of hypertension and other cardiovascular events than men of the same age, but diminished sex differences after menopause implicates 17-beta-estradiol (E2) as a protective agent. The cardioprotective effects of E2 are mediated by nuclear estrogen receptors (ERα and ERβ) and a G protein-coupled estrogen receptor (GPER). This review summarizes both established as well as emerging estrogen-mediated mechanisms that underlie sex differences in the vasculature during hypertension and CVD. In addition, remaining knowledge gaps inherent in the association of sex differences and E2 are identified, which may guide future clinical trials and experimental studies in this field.
AB - Cardiovascular disease (CVD) is the leading cause of death globally for men and women. Premenopausal women have a lower incidence of hypertension and other cardiovascular events than men of the same age, but diminished sex differences after menopause implicates 17-beta-estradiol (E2) as a protective agent. The cardioprotective effects of E2 are mediated by nuclear estrogen receptors (ERα and ERβ) and a G protein-coupled estrogen receptor (GPER). This review summarizes both established as well as emerging estrogen-mediated mechanisms that underlie sex differences in the vasculature during hypertension and CVD. In addition, remaining knowledge gaps inherent in the association of sex differences and E2 are identified, which may guide future clinical trials and experimental studies in this field.
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U2 - 10.1038/s41371-022-00771-0
DO - 10.1038/s41371-022-00771-0
M3 - Review article
C2 - 36319856
AN - SCOPUS:85141090164
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
SN - 0950-9240
ER -