Eugenia jambolana seed extract supplementation attenuates cardiac and hepatic oxidative stress and pathophysiological changes in hypercholesterolemic rats

Jayanta M. Sankhari, Ravirajsinh N. Jadeja, Menaka Thounaojam, Ranjitsinh V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The present study was aimed at evaluating protective role of Eugenia jambolana seed extract (EJSE) on high cholesterol diet (HCD) induced hyperlipidemia/hypercholesterolemia amounting to cardiac and hepatic oxidative stress. Serum markers of cardiac and hepatic damage, total lipid profile (serum, tissue and feces), lipid peroxidation, antioxidant status and histopathological changes in cardiac and hepatic tissue have been assessed in control, HCD fed and HCD+EJSE treated (100 mg/kg BW, p. o.) rats. It was observed that co-supplementation of EJSE to HCD fed rats significantly (p < 0. 05) minimized elevation in the serum, and tissue lipid profiles, decrement in the HDL level and resulted in higher elimination of lipids through feces. Also, EJSE successfully ameliorated HCD induced cardiac and hepatic oxidative stress (p < 0. 05) and histopathological damage. It can be concluded that, EJSE has the potential of preventing HCD induced experimental hypercholesterolemia and, related cardiac and hepatic oxidative stress. Its therapeutic potential against HCD induced hypercholesterolemia and subsequent oxidative stress mediated cardiac and hepatic damage is indicated.

Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
JournalOriental Pharmacy and Experimental Medicine
Volume12
Issue number2
DOIs
StatePublished - Oct 4 2012
Externally publishedYes

Fingerprint

Syzygium
Seeds
Oxidative Stress
Cholesterol
Diet
Liver
Hypercholesterolemia
Lipids
Feces
Hyperlipidemias
Serum
Lipid Peroxidation
Antioxidants
Biomarkers

Keywords

  • Eugenia jambolana
  • Histopathology
  • Hyperlipidemia
  • Oxidative stress

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Eugenia jambolana seed extract supplementation attenuates cardiac and hepatic oxidative stress and pathophysiological changes in hypercholesterolemic rats. / Sankhari, Jayanta M.; Jadeja, Ravirajsinh N.; Thounaojam, Menaka; Devkar, Ranjitsinh V.; Ramachandran, A. V.

In: Oriental Pharmacy and Experimental Medicine, Vol. 12, No. 2, 04.10.2012, p. 99-106.

Research output: Contribution to journalArticle

@article{27b604d6480449f8b85c95b677606436,
title = "Eugenia jambolana seed extract supplementation attenuates cardiac and hepatic oxidative stress and pathophysiological changes in hypercholesterolemic rats",
abstract = "The present study was aimed at evaluating protective role of Eugenia jambolana seed extract (EJSE) on high cholesterol diet (HCD) induced hyperlipidemia/hypercholesterolemia amounting to cardiac and hepatic oxidative stress. Serum markers of cardiac and hepatic damage, total lipid profile (serum, tissue and feces), lipid peroxidation, antioxidant status and histopathological changes in cardiac and hepatic tissue have been assessed in control, HCD fed and HCD+EJSE treated (100 mg/kg BW, p. o.) rats. It was observed that co-supplementation of EJSE to HCD fed rats significantly (p < 0. 05) minimized elevation in the serum, and tissue lipid profiles, decrement in the HDL level and resulted in higher elimination of lipids through feces. Also, EJSE successfully ameliorated HCD induced cardiac and hepatic oxidative stress (p < 0. 05) and histopathological damage. It can be concluded that, EJSE has the potential of preventing HCD induced experimental hypercholesterolemia and, related cardiac and hepatic oxidative stress. Its therapeutic potential against HCD induced hypercholesterolemia and subsequent oxidative stress mediated cardiac and hepatic damage is indicated.",
keywords = "Eugenia jambolana, Histopathology, Hyperlipidemia, Oxidative stress",
author = "Sankhari, {Jayanta M.} and Jadeja, {Ravirajsinh N.} and Menaka Thounaojam and Devkar, {Ranjitsinh V.} and Ramachandran, {A. V.}",
year = "2012",
month = "10",
day = "4",
doi = "10.1007/s13596-012-0056-4",
language = "English (US)",
volume = "12",
pages = "99--106",
journal = "Oriental Pharmacy and Experimental Medicine",
issn = "1598-2386",
publisher = "Springer Science + Business Media",
number = "2",

}

TY - JOUR

T1 - Eugenia jambolana seed extract supplementation attenuates cardiac and hepatic oxidative stress and pathophysiological changes in hypercholesterolemic rats

AU - Sankhari, Jayanta M.

AU - Jadeja, Ravirajsinh N.

AU - Thounaojam, Menaka

AU - Devkar, Ranjitsinh V.

AU - Ramachandran, A. V.

PY - 2012/10/4

Y1 - 2012/10/4

N2 - The present study was aimed at evaluating protective role of Eugenia jambolana seed extract (EJSE) on high cholesterol diet (HCD) induced hyperlipidemia/hypercholesterolemia amounting to cardiac and hepatic oxidative stress. Serum markers of cardiac and hepatic damage, total lipid profile (serum, tissue and feces), lipid peroxidation, antioxidant status and histopathological changes in cardiac and hepatic tissue have been assessed in control, HCD fed and HCD+EJSE treated (100 mg/kg BW, p. o.) rats. It was observed that co-supplementation of EJSE to HCD fed rats significantly (p < 0. 05) minimized elevation in the serum, and tissue lipid profiles, decrement in the HDL level and resulted in higher elimination of lipids through feces. Also, EJSE successfully ameliorated HCD induced cardiac and hepatic oxidative stress (p < 0. 05) and histopathological damage. It can be concluded that, EJSE has the potential of preventing HCD induced experimental hypercholesterolemia and, related cardiac and hepatic oxidative stress. Its therapeutic potential against HCD induced hypercholesterolemia and subsequent oxidative stress mediated cardiac and hepatic damage is indicated.

AB - The present study was aimed at evaluating protective role of Eugenia jambolana seed extract (EJSE) on high cholesterol diet (HCD) induced hyperlipidemia/hypercholesterolemia amounting to cardiac and hepatic oxidative stress. Serum markers of cardiac and hepatic damage, total lipid profile (serum, tissue and feces), lipid peroxidation, antioxidant status and histopathological changes in cardiac and hepatic tissue have been assessed in control, HCD fed and HCD+EJSE treated (100 mg/kg BW, p. o.) rats. It was observed that co-supplementation of EJSE to HCD fed rats significantly (p < 0. 05) minimized elevation in the serum, and tissue lipid profiles, decrement in the HDL level and resulted in higher elimination of lipids through feces. Also, EJSE successfully ameliorated HCD induced cardiac and hepatic oxidative stress (p < 0. 05) and histopathological damage. It can be concluded that, EJSE has the potential of preventing HCD induced experimental hypercholesterolemia and, related cardiac and hepatic oxidative stress. Its therapeutic potential against HCD induced hypercholesterolemia and subsequent oxidative stress mediated cardiac and hepatic damage is indicated.

KW - Eugenia jambolana

KW - Histopathology

KW - Hyperlipidemia

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84866871662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866871662&partnerID=8YFLogxK

U2 - 10.1007/s13596-012-0056-4

DO - 10.1007/s13596-012-0056-4

M3 - Article

AN - SCOPUS:84866871662

VL - 12

SP - 99

EP - 106

JO - Oriental Pharmacy and Experimental Medicine

JF - Oriental Pharmacy and Experimental Medicine

SN - 1598-2386

IS - 2

ER -