Evaluation of a novel calcium phosphate-coated titanium porous oxide implant surface: A study in rabbits

Nicholas M. Poulos, Nancy A. Rodriguez, Jaebum Lee, Frederick A. Rueggeberg, Peter Schüpbach, Jan Hall, Cristiano Susin, Ulf M E Wikesjö

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To evaluate osseointegration of a novel calcium phosphate (CaP)-coated titanium porous oxide implant surface. Materials and Methods: Twenty adult male New Zealand White rabbits were used. Each animal received two titanium porous oxide-surfaced implants (benchmark control: TiUnite, Nobel Biocare) and two novel CaP-coated titanium porous oxide-surfaces implants; they were randomly allocated to contralateral tibia implant sites. The animals were sacrificed after 2 or 4 weeks, and tissues were evaluated histometrically. Results: Healing was generally uneventful. A removal torque analysis showed significantly higher mean (± SE) peak values for the control implants than for the test implants at 2 weeks (31.4 ± 2.5 Ncm versus 20.4 ± 1.8 Ncm) and 4 weeks (48.4 ± 5.5 Ncm versus 30.3 ± 3.9 Ncm). Light microscopy showed no significant differences in local bone density around control and test implants at 2 and 4 weeks (range, 85% to 91% within the thread area and 91% to 95% immediately outside the threads). At 2 weeks, bone-implant contact for control and test implants averaged 81.8% ± 2.8% and 75.7% ± 4.6%, respectively, and at 4 weeks the bone-implant contact values were 79.4% ± 2.8% and 73.5% ± 4.2%, respectively; these differences were not significant. Backscatter scanning electron microscopy also showed no significant differences in local bone density at control and test implants at 2 and 4 weeks (range, 55% to 72% within the thread area and 75% to 81% immediately outside the threads). At 2 weeks, bone-implant contact for control and test implants averaged 66.4% ± 2.9% and 61.5% ± 5.1%, respectively, and at 4 weeks mean values were 60.1% ± 4.2% and 53.3% ± 4.6% (differences not significant). Conclusions: The results suggest that the novel CaP-coated surface effectively supports osseointegration.

Original languageEnglish (US)
Pages (from-to)731-738
Number of pages8
JournalInternational Journal of Oral and Maxillofacial Implants
Volume26
Issue number4
StatePublished - Jan 1 2011

Fingerprint

Osseointegration
Rabbits
Bone and Bones
Bone Density
Benchmarking
Torque
Tibia
Electron Scanning Microscopy
Microscopy
Light
titanium dioxide
calcium phosphate

Keywords

  • Bone-implant contact
  • Calcium phosphate
  • Dental implants
  • Osseointegration
  • Titanium porous oxide

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Evaluation of a novel calcium phosphate-coated titanium porous oxide implant surface : A study in rabbits. / Poulos, Nicholas M.; Rodriguez, Nancy A.; Lee, Jaebum; Rueggeberg, Frederick A.; Schüpbach, Peter; Hall, Jan; Susin, Cristiano; Wikesjö, Ulf M E.

In: International Journal of Oral and Maxillofacial Implants, Vol. 26, No. 4, 01.01.2011, p. 731-738.

Research output: Contribution to journalArticle

Poulos, NM, Rodriguez, NA, Lee, J, Rueggeberg, FA, Schüpbach, P, Hall, J, Susin, C & Wikesjö, UME 2011, 'Evaluation of a novel calcium phosphate-coated titanium porous oxide implant surface: A study in rabbits', International Journal of Oral and Maxillofacial Implants, vol. 26, no. 4, pp. 731-738.
Poulos, Nicholas M. ; Rodriguez, Nancy A. ; Lee, Jaebum ; Rueggeberg, Frederick A. ; Schüpbach, Peter ; Hall, Jan ; Susin, Cristiano ; Wikesjö, Ulf M E. / Evaluation of a novel calcium phosphate-coated titanium porous oxide implant surface : A study in rabbits. In: International Journal of Oral and Maxillofacial Implants. 2011 ; Vol. 26, No. 4. pp. 731-738.
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abstract = "Purpose: To evaluate osseointegration of a novel calcium phosphate (CaP)-coated titanium porous oxide implant surface. Materials and Methods: Twenty adult male New Zealand White rabbits were used. Each animal received two titanium porous oxide-surfaced implants (benchmark control: TiUnite, Nobel Biocare) and two novel CaP-coated titanium porous oxide-surfaces implants; they were randomly allocated to contralateral tibia implant sites. The animals were sacrificed after 2 or 4 weeks, and tissues were evaluated histometrically. Results: Healing was generally uneventful. A removal torque analysis showed significantly higher mean (± SE) peak values for the control implants than for the test implants at 2 weeks (31.4 ± 2.5 Ncm versus 20.4 ± 1.8 Ncm) and 4 weeks (48.4 ± 5.5 Ncm versus 30.3 ± 3.9 Ncm). Light microscopy showed no significant differences in local bone density around control and test implants at 2 and 4 weeks (range, 85{\%} to 91{\%} within the thread area and 91{\%} to 95{\%} immediately outside the threads). At 2 weeks, bone-implant contact for control and test implants averaged 81.8{\%} ± 2.8{\%} and 75.7{\%} ± 4.6{\%}, respectively, and at 4 weeks the bone-implant contact values were 79.4{\%} ± 2.8{\%} and 73.5{\%} ± 4.2{\%}, respectively; these differences were not significant. Backscatter scanning electron microscopy also showed no significant differences in local bone density at control and test implants at 2 and 4 weeks (range, 55{\%} to 72{\%} within the thread area and 75{\%} to 81{\%} immediately outside the threads). At 2 weeks, bone-implant contact for control and test implants averaged 66.4{\%} ± 2.9{\%} and 61.5{\%} ± 5.1{\%}, respectively, and at 4 weeks mean values were 60.1{\%} ± 4.2{\%} and 53.3{\%} ± 4.6{\%} (differences not significant). Conclusions: The results suggest that the novel CaP-coated surface effectively supports osseointegration.",
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N2 - Purpose: To evaluate osseointegration of a novel calcium phosphate (CaP)-coated titanium porous oxide implant surface. Materials and Methods: Twenty adult male New Zealand White rabbits were used. Each animal received two titanium porous oxide-surfaced implants (benchmark control: TiUnite, Nobel Biocare) and two novel CaP-coated titanium porous oxide-surfaces implants; they were randomly allocated to contralateral tibia implant sites. The animals were sacrificed after 2 or 4 weeks, and tissues were evaluated histometrically. Results: Healing was generally uneventful. A removal torque analysis showed significantly higher mean (± SE) peak values for the control implants than for the test implants at 2 weeks (31.4 ± 2.5 Ncm versus 20.4 ± 1.8 Ncm) and 4 weeks (48.4 ± 5.5 Ncm versus 30.3 ± 3.9 Ncm). Light microscopy showed no significant differences in local bone density around control and test implants at 2 and 4 weeks (range, 85% to 91% within the thread area and 91% to 95% immediately outside the threads). At 2 weeks, bone-implant contact for control and test implants averaged 81.8% ± 2.8% and 75.7% ± 4.6%, respectively, and at 4 weeks the bone-implant contact values were 79.4% ± 2.8% and 73.5% ± 4.2%, respectively; these differences were not significant. Backscatter scanning electron microscopy also showed no significant differences in local bone density at control and test implants at 2 and 4 weeks (range, 55% to 72% within the thread area and 75% to 81% immediately outside the threads). At 2 weeks, bone-implant contact for control and test implants averaged 66.4% ± 2.9% and 61.5% ± 5.1%, respectively, and at 4 weeks mean values were 60.1% ± 4.2% and 53.3% ± 4.6% (differences not significant). Conclusions: The results suggest that the novel CaP-coated surface effectively supports osseointegration.

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