Evaluation of crossed cerebellar diaschisis in 30 patients with major cerebral artery occlusion by means of quantitative I-123 IMP SPECT

Nobuhiko Miyazawa, Keiji Toyama, Ali Syed Arbab, Kiyoshi Koizumi, Takao Arai, Hideaki Nukui

Research output: Contribution to journalArticle

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Abstract

Quantitative crossed cerebellar diaschisis (CCD) and the correlation with a reduction in supratentorial regional cerebral blood flow (rCBF) and cerebrovascular reserve capacity (CVR) were investigated in clinically stable patients with major cerebral artery occlusion by the iodine-123-Nisopropyl-p-iodoamphetamine (I-123 IMP) single photon emission computed tomography (SPECT) method. Thirty patients with major cerebral artery occlusion underwent SPECT by the I-123 IMP autoradiographic method. Regional CBF was measured in the cerebral hemisphere, frontal and parietal lobes, temporo-parietal lobe, and cerebellum both at rest and after administration of acetazolamide. Eighteen of 30 patients (60%) had CCD. CCD was significantly related to magnetic resonance imaging evidence of infarction. Quantitative CCD was 17% and the CVR in the cerebellum was preserved in patients with CCD. There was a significant difference in CBF and CVR between the affected and normal sides in all regions of interest in the patients without CCD [CBF (ml/100 g/min): hemisphere (H), normal side (N): 31.4 ± 6.8, affected side (A): 27.5 ± 7.4; p < 0.05. CVR: H, N: 0.56 ± 0.38, A: 0.42 ± 0.18; p < 0.01]. CCD is common in patients with major cerebral artery occlusion, and quantitative I-123 IMP SPECT is helpful in detecting CCD in clinically stable patients with occlusion of major cerebral arteries.

Original languageEnglish (US)
Pages (from-to)513-519
Number of pages7
JournalAnnals of Nuclear Medicine
Volume15
Issue number6
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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Cerebral Arteries
Single-Photon Emission-Computed Tomography
Iodine
Parietal Lobe
Cerebellum
Cerebrovascular Circulation
Acetazolamide
Regional Blood Flow
Cerebrum
Frontal Lobe
Infarction
Magnetic Resonance Imaging

Keywords

  • Cerebral artery
  • Crossed cerebellar diaschisis
  • I-IMP
  • Occlusion
  • SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Evaluation of crossed cerebellar diaschisis in 30 patients with major cerebral artery occlusion by means of quantitative I-123 IMP SPECT. / Miyazawa, Nobuhiko; Toyama, Keiji; Arbab, Ali Syed; Koizumi, Kiyoshi; Arai, Takao; Nukui, Hideaki.

In: Annals of Nuclear Medicine, Vol. 15, No. 6, 01.01.2001, p. 513-519.

Research output: Contribution to journalArticle

Miyazawa, Nobuhiko ; Toyama, Keiji ; Arbab, Ali Syed ; Koizumi, Kiyoshi ; Arai, Takao ; Nukui, Hideaki. / Evaluation of crossed cerebellar diaschisis in 30 patients with major cerebral artery occlusion by means of quantitative I-123 IMP SPECT. In: Annals of Nuclear Medicine. 2001 ; Vol. 15, No. 6. pp. 513-519.
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abstract = "Quantitative crossed cerebellar diaschisis (CCD) and the correlation with a reduction in supratentorial regional cerebral blood flow (rCBF) and cerebrovascular reserve capacity (CVR) were investigated in clinically stable patients with major cerebral artery occlusion by the iodine-123-Nisopropyl-p-iodoamphetamine (I-123 IMP) single photon emission computed tomography (SPECT) method. Thirty patients with major cerebral artery occlusion underwent SPECT by the I-123 IMP autoradiographic method. Regional CBF was measured in the cerebral hemisphere, frontal and parietal lobes, temporo-parietal lobe, and cerebellum both at rest and after administration of acetazolamide. Eighteen of 30 patients (60{\%}) had CCD. CCD was significantly related to magnetic resonance imaging evidence of infarction. Quantitative CCD was 17{\%} and the CVR in the cerebellum was preserved in patients with CCD. There was a significant difference in CBF and CVR between the affected and normal sides in all regions of interest in the patients without CCD [CBF (ml/100 g/min): hemisphere (H), normal side (N): 31.4 ± 6.8, affected side (A): 27.5 ± 7.4; p < 0.05. CVR: H, N: 0.56 ± 0.38, A: 0.42 ± 0.18; p < 0.01]. CCD is common in patients with major cerebral artery occlusion, and quantitative I-123 IMP SPECT is helpful in detecting CCD in clinically stable patients with occlusion of major cerebral arteries.",
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