Evaluation of implants coated with rhBMP-2 using two different coating strategies

A critical-size supraalveolar peri-implant defect study in dogs

Jaebum Lee, John F. Decker, Giuseppe Polimeni, Carlo Alberto Cortella, Michael D. Rohrer, John M. Wozney, Jan Hall, Cristiano Susin, Ulf M E Wikesjö

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Implants coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) induce relevant bone formation but also resident bone remodelling. Objectives: To compare the effect of implants fully or partially coated with rhBMP-2 on new bone formation and resident bone remodelling. Materials and Methods: Twelve, male, adult, Hound Labrador mongrel dogs were used. Critical-size, supraalveolar, peri-implant defects received titanium porous oxide surface implants coated in their most coronal aspect with rhBMP-2 (coronal-load/six animals) or by immersion of the entire implant in an rhBMP-2 solution (soak-load/six animals) for a total of 30 μg rhBMP-2/implant. All implants were air-dried. The animals were euthanized at 8 weeks for histometric evaluation. Results: Clinical healing was uneventful. Supraalveolar bone formation was not significantly affected by the rhBMP-2 application protocol. New bone height and area averaged (± SE) 3.4 ± 0.2 versus 3.5 ± 0.4 mm and 2.6 ± 0.4 versus 2.5 ± 0.7 mm2 for coronal-load and soak-load implants, respectively (p>0.05). The corresponding bone density and bone-implant contact (BIC) recordings averaged 38.0 ± 3.8% versus 34.4 ± 5.6% and 25.0 ± 3.8% versus 31.2 ± 3.3% (p>0.05). In contrast, resident bone remodelling was significantly influenced by the rhBMP-2 application protocol. Bone density outside the implants threads averaged 74.7 ± 3.8% and 50.8 ± 4.1% for coronal-load and soak-load implants, respectively (p<0.05); bone density within the thread area averaged 51.8 ± 1.2% and 37.8 ± 2.9%, and BIC 70.1 ± 6.7% and 43.3 ± 3.9% (p<0.05). Conclusion: Local application of rhBMP-2 appears to be a viable technology to support local bone formation and osseointegration. Coronal-load implants obviate resident bone remodelling without compromising new bone formation.

Original languageEnglish (US)
Pages (from-to)582-590
Number of pages9
JournalJournal of Clinical Periodontology
Volume37
Issue number6
DOIs
StatePublished - Jun 1 2010

Fingerprint

Dogs
Osteogenesis
Bone Remodeling
Bone Density
Bone and Bones
Newfoundland and Labrador
Osseointegration
recombinant human bone morphogenetic protein-2
Immersion
Air
Technology

Keywords

  • Bone density
  • Bone formation
  • Bone remodelling
  • Dental implant
  • Osseointegration
  • RhBMP-2
  • Tissue engineering

ASJC Scopus subject areas

  • Periodontics

Cite this

Evaluation of implants coated with rhBMP-2 using two different coating strategies : A critical-size supraalveolar peri-implant defect study in dogs. / Lee, Jaebum; Decker, John F.; Polimeni, Giuseppe; Cortella, Carlo Alberto; Rohrer, Michael D.; Wozney, John M.; Hall, Jan; Susin, Cristiano; Wikesjö, Ulf M E.

In: Journal of Clinical Periodontology, Vol. 37, No. 6, 01.06.2010, p. 582-590.

Research output: Contribution to journalArticle

Lee, Jaebum ; Decker, John F. ; Polimeni, Giuseppe ; Cortella, Carlo Alberto ; Rohrer, Michael D. ; Wozney, John M. ; Hall, Jan ; Susin, Cristiano ; Wikesjö, Ulf M E. / Evaluation of implants coated with rhBMP-2 using two different coating strategies : A critical-size supraalveolar peri-implant defect study in dogs. In: Journal of Clinical Periodontology. 2010 ; Vol. 37, No. 6. pp. 582-590.
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abstract = "Background: Implants coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) induce relevant bone formation but also resident bone remodelling. Objectives: To compare the effect of implants fully or partially coated with rhBMP-2 on new bone formation and resident bone remodelling. Materials and Methods: Twelve, male, adult, Hound Labrador mongrel dogs were used. Critical-size, supraalveolar, peri-implant defects received titanium porous oxide surface implants coated in their most coronal aspect with rhBMP-2 (coronal-load/six animals) or by immersion of the entire implant in an rhBMP-2 solution (soak-load/six animals) for a total of 30 μg rhBMP-2/implant. All implants were air-dried. The animals were euthanized at 8 weeks for histometric evaluation. Results: Clinical healing was uneventful. Supraalveolar bone formation was not significantly affected by the rhBMP-2 application protocol. New bone height and area averaged (± SE) 3.4 ± 0.2 versus 3.5 ± 0.4 mm and 2.6 ± 0.4 versus 2.5 ± 0.7 mm2 for coronal-load and soak-load implants, respectively (p>0.05). The corresponding bone density and bone-implant contact (BIC) recordings averaged 38.0 ± 3.8{\%} versus 34.4 ± 5.6{\%} and 25.0 ± 3.8{\%} versus 31.2 ± 3.3{\%} (p>0.05). In contrast, resident bone remodelling was significantly influenced by the rhBMP-2 application protocol. Bone density outside the implants threads averaged 74.7 ± 3.8{\%} and 50.8 ± 4.1{\%} for coronal-load and soak-load implants, respectively (p<0.05); bone density within the thread area averaged 51.8 ± 1.2{\%} and 37.8 ± 2.9{\%}, and BIC 70.1 ± 6.7{\%} and 43.3 ± 3.9{\%} (p<0.05). Conclusion: Local application of rhBMP-2 appears to be a viable technology to support local bone formation and osseointegration. Coronal-load implants obviate resident bone remodelling without compromising new bone formation.",
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author = "Jaebum Lee and Decker, {John F.} and Giuseppe Polimeni and Cortella, {Carlo Alberto} and Rohrer, {Michael D.} and Wozney, {John M.} and Jan Hall and Cristiano Susin and Wikesj{\"o}, {Ulf M E}",
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T2 - A critical-size supraalveolar peri-implant defect study in dogs

AU - Lee, Jaebum

AU - Decker, John F.

AU - Polimeni, Giuseppe

AU - Cortella, Carlo Alberto

AU - Rohrer, Michael D.

AU - Wozney, John M.

AU - Hall, Jan

AU - Susin, Cristiano

AU - Wikesjö, Ulf M E

PY - 2010/6/1

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N2 - Background: Implants coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) induce relevant bone formation but also resident bone remodelling. Objectives: To compare the effect of implants fully or partially coated with rhBMP-2 on new bone formation and resident bone remodelling. Materials and Methods: Twelve, male, adult, Hound Labrador mongrel dogs were used. Critical-size, supraalveolar, peri-implant defects received titanium porous oxide surface implants coated in their most coronal aspect with rhBMP-2 (coronal-load/six animals) or by immersion of the entire implant in an rhBMP-2 solution (soak-load/six animals) for a total of 30 μg rhBMP-2/implant. All implants were air-dried. The animals were euthanized at 8 weeks for histometric evaluation. Results: Clinical healing was uneventful. Supraalveolar bone formation was not significantly affected by the rhBMP-2 application protocol. New bone height and area averaged (± SE) 3.4 ± 0.2 versus 3.5 ± 0.4 mm and 2.6 ± 0.4 versus 2.5 ± 0.7 mm2 for coronal-load and soak-load implants, respectively (p>0.05). The corresponding bone density and bone-implant contact (BIC) recordings averaged 38.0 ± 3.8% versus 34.4 ± 5.6% and 25.0 ± 3.8% versus 31.2 ± 3.3% (p>0.05). In contrast, resident bone remodelling was significantly influenced by the rhBMP-2 application protocol. Bone density outside the implants threads averaged 74.7 ± 3.8% and 50.8 ± 4.1% for coronal-load and soak-load implants, respectively (p<0.05); bone density within the thread area averaged 51.8 ± 1.2% and 37.8 ± 2.9%, and BIC 70.1 ± 6.7% and 43.3 ± 3.9% (p<0.05). Conclusion: Local application of rhBMP-2 appears to be a viable technology to support local bone formation and osseointegration. Coronal-load implants obviate resident bone remodelling without compromising new bone formation.

AB - Background: Implants coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) induce relevant bone formation but also resident bone remodelling. Objectives: To compare the effect of implants fully or partially coated with rhBMP-2 on new bone formation and resident bone remodelling. Materials and Methods: Twelve, male, adult, Hound Labrador mongrel dogs were used. Critical-size, supraalveolar, peri-implant defects received titanium porous oxide surface implants coated in their most coronal aspect with rhBMP-2 (coronal-load/six animals) or by immersion of the entire implant in an rhBMP-2 solution (soak-load/six animals) for a total of 30 μg rhBMP-2/implant. All implants were air-dried. The animals were euthanized at 8 weeks for histometric evaluation. Results: Clinical healing was uneventful. Supraalveolar bone formation was not significantly affected by the rhBMP-2 application protocol. New bone height and area averaged (± SE) 3.4 ± 0.2 versus 3.5 ± 0.4 mm and 2.6 ± 0.4 versus 2.5 ± 0.7 mm2 for coronal-load and soak-load implants, respectively (p>0.05). The corresponding bone density and bone-implant contact (BIC) recordings averaged 38.0 ± 3.8% versus 34.4 ± 5.6% and 25.0 ± 3.8% versus 31.2 ± 3.3% (p>0.05). In contrast, resident bone remodelling was significantly influenced by the rhBMP-2 application protocol. Bone density outside the implants threads averaged 74.7 ± 3.8% and 50.8 ± 4.1% for coronal-load and soak-load implants, respectively (p<0.05); bone density within the thread area averaged 51.8 ± 1.2% and 37.8 ± 2.9%, and BIC 70.1 ± 6.7% and 43.3 ± 3.9% (p<0.05). Conclusion: Local application of rhBMP-2 appears to be a viable technology to support local bone formation and osseointegration. Coronal-load implants obviate resident bone remodelling without compromising new bone formation.

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KW - Bone formation

KW - Bone remodelling

KW - Dental implant

KW - Osseointegration

KW - RhBMP-2

KW - Tissue engineering

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