Evaluation of leuprolide acetate treatment on histopathology of uterine myomata

J. N. Gutmann, K. L. Thornton, Michael Peter Diamond, M. L. Carcangiu

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: To determine if short-term, preoperative leuprolide acetate (LA) therapy alters the histologic appearance of uterine leiomyomata. Design: Retrospective evaluation by a pathologist (who was blinded to patient history) of the histologic features of leiomyomata excised from 36 women, 12 who received preoperative LA and 24 age-matched controls. Setting: Yale-New Haven Hospital, New Haven, Connecticut, from September 1989 to September 1990. Main Outcome Measure: The histologic specimens were evaluated for the presence of mitotic activity, cellular atypia, cellularity, and secondary changes including edema, fibrosis, calcification, hemorrhage, infarction, hyalinization, and vascular appearance. Results: Of the 12 patients treated with LA, 10 (84%) demonstrated a reduction in uterine volume after 3 to 6 months of LA therapy. There was no difference in any of the histopathologic parameters evaluated between the LA-treated group and the untreated group. Exclusion of leiomyoma, which did not have a reduction in size during LA therapy, did not alter the analysis. Among patients treated with LA, those leiomyoma that did not respond to LA had a greater degree of hyalinization than those that responded. Conclusion: Reduction in uterine size by short- term LA therapy did not detectably alter histologic appearance of leiomyoma.

Original languageEnglish (US)
Pages (from-to)622-626
Number of pages5
JournalFertility and Sterility
Volume61
Issue number4
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Leuprolide
Myoma
Leiomyoma
Therapeutics
Infarction
Blood Vessels
Edema
Fibrosis
Outcome Assessment (Health Care)
Hemorrhage

Keywords

  • Gonadotropin-releasing hormone analogue
  • histopathology
  • leiomyomata

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Gutmann, J. N., Thornton, K. L., Diamond, M. P., & Carcangiu, M. L. (1994). Evaluation of leuprolide acetate treatment on histopathology of uterine myomata. Fertility and Sterility, 61(4), 622-626.

Evaluation of leuprolide acetate treatment on histopathology of uterine myomata. / Gutmann, J. N.; Thornton, K. L.; Diamond, Michael Peter; Carcangiu, M. L.

In: Fertility and Sterility, Vol. 61, No. 4, 01.01.1994, p. 622-626.

Research output: Contribution to journalArticle

Gutmann, JN, Thornton, KL, Diamond, MP & Carcangiu, ML 1994, 'Evaluation of leuprolide acetate treatment on histopathology of uterine myomata', Fertility and Sterility, vol. 61, no. 4, pp. 622-626.
Gutmann, J. N. ; Thornton, K. L. ; Diamond, Michael Peter ; Carcangiu, M. L. / Evaluation of leuprolide acetate treatment on histopathology of uterine myomata. In: Fertility and Sterility. 1994 ; Vol. 61, No. 4. pp. 622-626.
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