Evaluation of metallothionein and p53 expression as potential prognostic markers for laryngeal squamous cell carcinoma.

Jimmy J Brown, H. Xu, L. William-Smith, H. Mohamed, S. Teklehaimanot, J. Zhuo, R. Osborne, F. Liu, R. E. Gowans, J. Nishitani, X. Liu

Research output: Contribution to journalArticle

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Abstract

The aim of the study was to determine the contribution of metallothionein (MT) and p53 expression in predicting laryngeal squamous cell carcinoma (SCC) recurrence. This was a retrospective study in which MT and p53 immunopositive staining in 32 laryngeal SCC paraffin-embedded sections, were correlated with clinical recurrence. Recurrence was observed in 8 cases with MT expression (42.1%) and 1 case with no expression (7.7%). Moderate and strong MT expression was associated with 14.3% and 58.3% recurrence, respectively. Recurrence was similar for both p53-negative (21.1%) and p53-positive (27.3%) groups. One third of the patients expressing both p53 and MT simultaneously had recurrence. Thus, the combined expression of p53 and MT did not improve the predictive value for recurrence compared to MT alone. MT over-expression may be an independent risk factor for laryngeal SCC recurrence.

Original languageEnglish (US)
JournalCellular and molecular biology (Noisy-le-Grand, France)
Volume49 Online Pub
StatePublished - Jan 1 2003

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Metallothionein
Squamous Cell Carcinoma
Recurrence
Epithelial Cells
Paraffin
Retrospective Studies
Staining and Labeling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Brown, J. J., Xu, H., William-Smith, L., Mohamed, H., Teklehaimanot, S., Zhuo, J., ... Liu, X. (2003). Evaluation of metallothionein and p53 expression as potential prognostic markers for laryngeal squamous cell carcinoma. Cellular and molecular biology (Noisy-le-Grand, France), 49 Online Pub.

Evaluation of metallothionein and p53 expression as potential prognostic markers for laryngeal squamous cell carcinoma. / Brown, Jimmy J; Xu, H.; William-Smith, L.; Mohamed, H.; Teklehaimanot, S.; Zhuo, J.; Osborne, R.; Liu, F.; Gowans, R. E.; Nishitani, J.; Liu, X.

In: Cellular and molecular biology (Noisy-le-Grand, France), Vol. 49 Online Pub, 01.01.2003.

Research output: Contribution to journalArticle

Brown, JJ, Xu, H, William-Smith, L, Mohamed, H, Teklehaimanot, S, Zhuo, J, Osborne, R, Liu, F, Gowans, RE, Nishitani, J & Liu, X 2003, 'Evaluation of metallothionein and p53 expression as potential prognostic markers for laryngeal squamous cell carcinoma.', Cellular and molecular biology (Noisy-le-Grand, France), vol. 49 Online Pub.
Brown, Jimmy J ; Xu, H. ; William-Smith, L. ; Mohamed, H. ; Teklehaimanot, S. ; Zhuo, J. ; Osborne, R. ; Liu, F. ; Gowans, R. E. ; Nishitani, J. ; Liu, X. / Evaluation of metallothionein and p53 expression as potential prognostic markers for laryngeal squamous cell carcinoma. In: Cellular and molecular biology (Noisy-le-Grand, France). 2003 ; Vol. 49 Online Pub.
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abstract = "The aim of the study was to determine the contribution of metallothionein (MT) and p53 expression in predicting laryngeal squamous cell carcinoma (SCC) recurrence. This was a retrospective study in which MT and p53 immunopositive staining in 32 laryngeal SCC paraffin-embedded sections, were correlated with clinical recurrence. Recurrence was observed in 8 cases with MT expression (42.1{\%}) and 1 case with no expression (7.7{\%}). Moderate and strong MT expression was associated with 14.3{\%} and 58.3{\%} recurrence, respectively. Recurrence was similar for both p53-negative (21.1{\%}) and p53-positive (27.3{\%}) groups. One third of the patients expressing both p53 and MT simultaneously had recurrence. Thus, the combined expression of p53 and MT did not improve the predictive value for recurrence compared to MT alone. MT over-expression may be an independent risk factor for laryngeal SCC recurrence.",
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AU - Teklehaimanot, S.

AU - Zhuo, J.

AU - Osborne, R.

AU - Liu, F.

AU - Gowans, R. E.

AU - Nishitani, J.

AU - Liu, X.

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