Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer's disease

Jie Gao, Bao Ling Adam, Alvin V. Terry

Research output: Contribution to journalArticle

29 Scopus citations


The currently available therapies for Alzheimer's disease (AD) and related forms of dementia are limited by modest efficacy, adverse side effects, and the fact that they do not prevent the relentless progression of the illness. The purpose of the studies described here was to investigate the neuroprotective effects of the nicotine metabolite cotinine as well as a small series of cotinine and nicotine analogs (including stereoisomers) and to compare their effects to the four clinically prescribed AD therapies.

Original languageEnglish (US)
Pages (from-to)1472-1478
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
Publication statusPublished - Mar 15 2014



  • Amyloid
  • Dementia
  • Disease modifying
  • Excitotoxicity
  • Glutamate
  • Multi-target-directed ligands
  • Multifunctional compounds
  • Neurodegeneration
  • Neuroprotection
  • Nicotinic

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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