Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer's disease

Jie Gao; Bao Ling Adam; Alvin V. Terry

doi:10.1016/j.bmcl.2014.02.008

Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer's disease

Jie Gao, Bao Ling Adam, Alvin V. Terry

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The currently available therapies for Alzheimer's disease (AD) and related forms of dementia are limited by modest efficacy, adverse side effects, and the fact that they do not prevent the relentless progression of the illness. The purpose of the studies described here was to investigate the neuroprotective effects of the nicotine metabolite cotinine as well as a small series of cotinine and nicotine analogs (including stereoisomers) and to compare their effects to the four clinically prescribed AD therapies.

Original language	English (US)
Pages (from-to)	1472-1478
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2014.02.008
State	Published - Mar 15 2014

Keywords

Amyloid
Dementia
Disease modifying
Excitotoxicity
Glutamate
Multi-target-directed ligands
Multifunctional compounds
Neurodegeneration
Neuroprotection
Nicotinic

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2014.02.008

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title = "Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer's disease",

abstract = "The currently available therapies for Alzheimer's disease (AD) and related forms of dementia are limited by modest efficacy, adverse side effects, and the fact that they do not prevent the relentless progression of the illness. The purpose of the studies described here was to investigate the neuroprotective effects of the nicotine metabolite cotinine as well as a small series of cotinine and nicotine analogs (including stereoisomers) and to compare their effects to the four clinically prescribed AD therapies.",

keywords = "Amyloid, Dementia, Disease modifying, Excitotoxicity, Glutamate, Multi-target-directed ligands, Multifunctional compounds, Neurodegeneration, Neuroprotection, Nicotinic",

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AU - Adam, Bao Ling

AU - Terry, Alvin V.

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Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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