Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36

Mark Gibbs, Janet L. Stanford, Richard A McIndoe, Gail P. Jarvik, Suzanne Kolb, Ellen L. Goode, Lisa Chakrabarti, Eugene F. Schuster, Valerie A. Buckley, Elizabeth L. Miller, Susan Brandzel, Sarah Li, Leroy Hood, Elaine A. Ostrander

Research output: Contribution to journalArticle

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Abstract

Combining data from a genomic screen in 70 families with a high risk for prostate cancer (PC) with data from candidate- region mapping in these families and an additional 71 families, we have localized a potential hereditary PC-susceptibility locus to chromosome 1p36. Because an excess of cases of primary brain cancer (BC) have been observed in some studies of families with a high risk for PC, and because loss of heterozygosity at 1p36 is frequently observed in BC, we further evaluated 12 families with both a history of PC and a blood relative with primary BC. The overall LOD score in these 12 families was 3.22 at a recombination fraction (0) of .06, with marker D1S507. On the basis of an a priori hypothesis, this group was stratified by age at diagnosis of PC. In the younger age group (mean age at diagnosis <66 years), a maximum two-point LOD score of 3.65 at 0 = .0 was observed, with D1S407. This linkage was rejected in both early- and late-onset families without a history of BC (LOD scores -7.12 and -6.03, respectively, at 0 = .0). After exclusion of 3 of the 12 families that had better evidence of linkage to previously described PC-susceptibility loci, linkage to the 1p36 region was suggested by a two-point LOD score of 4.74 at 0 = .0, with marker D1S407. We conclude that a significant proportion of these families with both a high risk for PC and a family member with BC show linkage to the 1p36 region.

Original languageEnglish (US)
Pages (from-to)776-787
Number of pages12
JournalAmerican Journal of Human Genetics
Volume64
Issue number3
DOIs
StatePublished - Jan 1 1999

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Prostatic Neoplasms
Chromosomes
Brain Neoplasms
Loss of Heterozygosity
Genetic Recombination
Age Groups

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Gibbs, M., Stanford, J. L., McIndoe, R. A., Jarvik, G. P., Kolb, S., Goode, E. L., ... Ostrander, E. A. (1999). Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. American Journal of Human Genetics, 64(3), 776-787. https://doi.org/10.1086/302287

Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. / Gibbs, Mark; Stanford, Janet L.; McIndoe, Richard A; Jarvik, Gail P.; Kolb, Suzanne; Goode, Ellen L.; Chakrabarti, Lisa; Schuster, Eugene F.; Buckley, Valerie A.; Miller, Elizabeth L.; Brandzel, Susan; Li, Sarah; Hood, Leroy; Ostrander, Elaine A.

In: American Journal of Human Genetics, Vol. 64, No. 3, 01.01.1999, p. 776-787.

Research output: Contribution to journalArticle

Gibbs, M, Stanford, JL, McIndoe, RA, Jarvik, GP, Kolb, S, Goode, EL, Chakrabarti, L, Schuster, EF, Buckley, VA, Miller, EL, Brandzel, S, Li, S, Hood, L & Ostrander, EA 1999, 'Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36', American Journal of Human Genetics, vol. 64, no. 3, pp. 776-787. https://doi.org/10.1086/302287
Gibbs, Mark ; Stanford, Janet L. ; McIndoe, Richard A ; Jarvik, Gail P. ; Kolb, Suzanne ; Goode, Ellen L. ; Chakrabarti, Lisa ; Schuster, Eugene F. ; Buckley, Valerie A. ; Miller, Elizabeth L. ; Brandzel, Susan ; Li, Sarah ; Hood, Leroy ; Ostrander, Elaine A. / Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. In: American Journal of Human Genetics. 1999 ; Vol. 64, No. 3. pp. 776-787.
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AU - Goode, Ellen L.

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AU - Buckley, Valerie A.

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