Evidence for field effect cancerization in colorectal cancer

Lesleyann Hawthorn, L. Lan, W. Mojica

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

We compared transcript expression, and chromosomal changes on a series of tumors and surrounding tissues to determine if there is evidence of field cancerization in colorectal cancer. Epithelial cells were isolated from tumors and areas adjacent to the tumors ranging from 1 to 10. cm. Tumor abnormalities mirrored those previously reported for colon cancer and while the number and size of the chromosomal abnormalities were greatly reduced in cells from surrounding regions, many chromosome abnormalities were discernable. Interestingly, these abnormalities were not consistent across the field in the same patient samples suggesting a field of chromosomal instability surrounding the tumor. A mutator phenotype has been proposed to account for this instability which states that the genotypes of cells within a tumor would not be identical, but would share at least a single mutation in any number of genes, or a selection of genes affecting a specific pathway which provide a proliferative advantage.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalGenomics
Volume103
Issue number2-3
DOIs
Publication statusPublished - Feb 2014

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Keywords

  • Chromosome copy number
  • Colon cancer
  • Field effect cancerization
  • LOH
  • Transcript expression

ASJC Scopus subject areas

  • Genetics

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