Evidence for pseudomonas antigen in immune complexes in pseudomonas osteomyelitis

Daniel W. Rahn, Allen C. Steere, Robert L. Grodzicki, Joseph H. Levine, John A. Hardin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In infections associated with immune complex disease, microbial antigens have rarely been found in the complexes. Using an enzyme‐linked immunoassay, we studied the immune complexes of a patient who had hematogenous Pseudomonas aeruginosa osteomyelitis associated with palpable purpura, arthritis, and microscopic hematuria. After separation of the complexes into high and low molecular weight fractions, a 6hyphen;fold selective concentration of P aeruginosa antibody was found in the low molecular weight fraction compared with the concentration in the serum. Following disruption of immunoglobulin, the high molecular weight fraction competed with solid‐phase P aeruginosa antigen for P aeruginosa antibody from another source. After successful treatment of the infection, the patient's symptoms resolved, and the complexes disappeared. These findings strongly suggest that immune complexes in this patient contained P aeruginosa antigen and antibody that may have been pathogenetic in his disease.

Original languageEnglish (US)
Pages (from-to)1403-1408
Number of pages6
JournalArthritis & Rheumatism
Volume25
Issue number12
DOIs
StatePublished - Dec 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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