Evidence of native α-synuclein conformers in the human brain

Neal Gould, Danielle E. Mor, Richard Lightfoot, Kristen Malkus, Benoit Giasson, Harry Ischiropoulos

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

α-Synuclein aggregation is central to the pathogenesis of several brain disorders. However, the native conformations and functions of this protein in the human brain are not precisely known. The native state of α-synuclein was probed by gel filtration coupled with native gradient gel separation, an array of antibodies with non-overlapping epitopes, and mass spectrometry. The existence of metastable conformers and stable monomer was revealed in the human brain.

Original languageEnglish (US)
Pages (from-to)7929-7934
Number of pages6
JournalJournal of Biological Chemistry
Volume289
Issue number11
DOIs
StatePublished - Mar 14 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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