Evidence of parthenogenetic origin of ovarian teratoma: Case report

Flávio Garcia Oliveira, Dmitri Dozortsev, Michael Peter Diamond, Adriana Fracasso, Soraya Abdelmassih, Vicente Abdelmassih, Sergio Pereira Gonçalves, Roger Abdelmassih, Zolt Peter Nagy

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Abstract

This case report represents one of the few documented cases of parthenote embryo retrieval from an IVF patient with a history of ovarian teratomas. A 29-year-old woman presented at our centre with a history of primary infertility for 6 years due to male factor. She had undergone left oophorectomy 4 years before due to an ovarian teratoma. An ultrasound scan performed during basal evaluation revealed two complex images in the right ovary suggesting teratomas, measuring 2.5 × 2.4 and 1.7 × 1.3 cm. A significant extent of sonographically normal ovarian parenchyma was present, and the patient underwent the long leuprolide acetate protocol of ovarian stimulation with recombinant FSH for an IVF-ICSI cycle. She had 13 metaphase II (MII), four metaphase I (MI), two germinal vesicle (GV) oocytes and one 4-cell embryo retrieved. Eight out of nine injected oocytes were fertilized normally while one was unfertilized. Embryo transfer was carried out 72 h after retrieval. The 4-cell (parthenote) embryo recovered at oocyte retrieval continued to cleave in culture, developing into a 7-cell embryo by the next. day. The embryo was morphologically normal, presenting an evident nucleus in each blastomere. Fluorescent in situ hybridization (FISH) returned two signals for the X chromosome in each blastomere that was analysed. Of the eight normally fertilized embryos, three were transferred, resulting in a normal singleton pregnancy and the birth of a healthy baby.

Original languageEnglish (US)
Pages (from-to)1867-1870
Number of pages4
JournalHuman Reproduction
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

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Keywords

  • Embryo
  • FISH
  • IVF-ICSI
  • Ovarian teratoma
  • Parthenogenetic oocyte activation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Garcia Oliveira, F., Dozortsev, D., Diamond, M. P., Fracasso, A., Abdelmassih, S., Abdelmassih, V., ... Nagy, Z. P. (2004). Evidence of parthenogenetic origin of ovarian teratoma: Case report. Human Reproduction, 19(8), 1867-1870. https://doi.org/10.1093/humrep/deh345