Evidence that renal arterial-venous oxygen shunting contributes to dynamic regulation of renal oxygenation

Chai Ling Leong, Warwick P. Anderson, Paul M O'Connor, Roger G. Evans

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Renal blood flow (RBF) can be reduced in rats and rabbits by up to 40% without significant changes in renal tissue PO2. We determined whether this occurs because renal oxygen consumption changes with RBF or due to some other mechanism. The relationships between RBF and renal cortical and medullary tissue PO2 and renal oxygen metabolism were determined in the denervated kidneys of anesthetized rabbits under hypoxic, normoxic, and hyperoxic conditions. During artificial ventilation with 21% oxygen (normoxia), RBF increased 32 ± 8% during renal arterial infusion of acetylcholine and reduced 31 ± 5% during ANG II infusion. Neither infusion significantly altered arterial pressure, tissue PO2 in the renal cortex or medulla, nor renal oxygen consumption. However, fractional oxygen extraction fell as RBF increased and the ratio of oxygen consumption to sodium reabsorption increased during ANG II infusion. Ventilation with 10% oxygen (hypoxia) significantly reduced both cortical and medullary PO2 (60-70%), whereas ventilation with 50% and 100% oxygen (hyperoxia) increased cortical and medullary PO 2 (by 62-298 and 30-56%, respectively). However, responses to altered RBF under hypoxic and hyperoxic conditions were similar to those under normoxic conditions. Thus renal tissue PO2 was relatively independent of RBF within a physiological range (±30%). This was not due to RBF-dependent changes in renal oxygen consumption. The observation that fractional extraction of oxygen fell with increased RBF, yet renal parenchymal PO2 remained unchanged, supports the hypothesis that preglomerular diffusional shunting of oxygen from arteries to veins increases with increasing RBF, and so contributes to dynamic regulation of intrarenal oxygenation.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Physiology
Volume292
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

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Renal Circulation
Oxygen
Kidney
Oxygen Consumption
Ventilation
Rabbits
Hyperoxia
Acetylcholine
Veins
Arterial Pressure
Arteries
Sodium

Keywords

  • Arteriovenous shunt
  • Diffusional shunt
  • Hypoxia
  • Ischemia

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Evidence that renal arterial-venous oxygen shunting contributes to dynamic regulation of renal oxygenation. / Leong, Chai Ling; Anderson, Warwick P.; O'Connor, Paul M; Evans, Roger G.

In: American Journal of Physiology - Renal Physiology, Vol. 292, No. 6, 01.06.2007.

Research output: Contribution to journalArticle

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AB - Renal blood flow (RBF) can be reduced in rats and rabbits by up to 40% without significant changes in renal tissue PO2. We determined whether this occurs because renal oxygen consumption changes with RBF or due to some other mechanism. The relationships between RBF and renal cortical and medullary tissue PO2 and renal oxygen metabolism were determined in the denervated kidneys of anesthetized rabbits under hypoxic, normoxic, and hyperoxic conditions. During artificial ventilation with 21% oxygen (normoxia), RBF increased 32 ± 8% during renal arterial infusion of acetylcholine and reduced 31 ± 5% during ANG II infusion. Neither infusion significantly altered arterial pressure, tissue PO2 in the renal cortex or medulla, nor renal oxygen consumption. However, fractional oxygen extraction fell as RBF increased and the ratio of oxygen consumption to sodium reabsorption increased during ANG II infusion. Ventilation with 10% oxygen (hypoxia) significantly reduced both cortical and medullary PO2 (60-70%), whereas ventilation with 50% and 100% oxygen (hyperoxia) increased cortical and medullary PO 2 (by 62-298 and 30-56%, respectively). However, responses to altered RBF under hypoxic and hyperoxic conditions were similar to those under normoxic conditions. Thus renal tissue PO2 was relatively independent of RBF within a physiological range (±30%). This was not due to RBF-dependent changes in renal oxygen consumption. The observation that fractional extraction of oxygen fell with increased RBF, yet renal parenchymal PO2 remained unchanged, supports the hypothesis that preglomerular diffusional shunting of oxygen from arteries to veins increases with increasing RBF, and so contributes to dynamic regulation of intrarenal oxygenation.

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