Evolution and expression of the transplantation antigen gene family

J. J. Devlin, G. Widera, A. Mellor, K. Fahrner, D. Sherman, E. H. Weiss, R. A. Flavell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have cloned 26 different class I genes that are located in the major histocompatibility complex of the C57BL/10 mouse. Two of the three class I genes found in the H-2 complex encode the H-2Kb and H-2Db antigens; the other 23 class I genes map to the adjacent Tla complex. We have grouped the cosmids containing these genes into three clusters: one cluster links the H-2K and I-A regions, one cluster links the H-2D and Qa-2 regions, and the final cluster maps to the TL region. The class I gene organizations in the Qa-2 and TL regions of the C57BL/10 and BALB/c mice are generally similar, but there are several polymorphic segments. The Qa-2 region of both mice seems to have evolved by the duplication of gene pairs; furthermore, the H-2K region may have been generated by the translocation of a gene pair from the Qa-2 region. We have evidence that several of the genes in the Qa-2 region are expressed.

Original languageEnglish (US)
Pages (from-to)2736-2740
Number of pages5
JournalFederation Proceedings
Volume44
Issue number11
StatePublished - Dec 1 1985

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MHC Class I Genes
Histocompatibility Antigens
Genes
Cosmids
Gene Duplication
Major Histocompatibility Complex
Inbred C57BL Mouse

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Devlin, J. J., Widera, G., Mellor, A., Fahrner, K., Sherman, D., Weiss, E. H., & Flavell, R. A. (1985). Evolution and expression of the transplantation antigen gene family. Federation Proceedings, 44(11), 2736-2740.

Evolution and expression of the transplantation antigen gene family. / Devlin, J. J.; Widera, G.; Mellor, A.; Fahrner, K.; Sherman, D.; Weiss, E. H.; Flavell, R. A.

In: Federation Proceedings, Vol. 44, No. 11, 01.12.1985, p. 2736-2740.

Research output: Contribution to journalArticle

Devlin, JJ, Widera, G, Mellor, A, Fahrner, K, Sherman, D, Weiss, EH & Flavell, RA 1985, 'Evolution and expression of the transplantation antigen gene family', Federation Proceedings, vol. 44, no. 11, pp. 2736-2740.
Devlin JJ, Widera G, Mellor A, Fahrner K, Sherman D, Weiss EH et al. Evolution and expression of the transplantation antigen gene family. Federation Proceedings. 1985 Dec 1;44(11):2736-2740.
Devlin, J. J. ; Widera, G. ; Mellor, A. ; Fahrner, K. ; Sherman, D. ; Weiss, E. H. ; Flavell, R. A. / Evolution and expression of the transplantation antigen gene family. In: Federation Proceedings. 1985 ; Vol. 44, No. 11. pp. 2736-2740.
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