Evolution and expression of the transplantation antigen gene family

J. J. Devlin, G. Widera, A. Mellor, K. Fahrner, D. Sherman, E. H. Weiss, R. A. Flavell

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Abstract

We have cloned 26 different class I genes that are located in the major histocompatibility complex of the C57BL/10 mouse. Two of the three class I genes found in the H-2 complex encode the H-2Kb and H-2Db antigens; the other 23 class I genes map to the adjacent Tla complex. We have grouped the cosmids containing these genes into three clusters: one cluster links the H-2K and I-A regions, one cluster links the H-2D and Qa-2 regions, and the final cluster maps to the TL region. The class I gene organizations in the Qa-2 and TL regions of the C57BL/10 and BALB/c mice are generally similar, but there are several polymorphic segments. The Qa-2 region of both mice seems to have evolved by the duplication of gene pairs; furthermore, the H-2K region may have been generated by the translocation of a gene pair from the Qa-2 region. We have evidence that several of the genes in the Qa-2 region are expressed.

Original languageEnglish (US)
Pages (from-to)2736-2740
Number of pages5
JournalFederation Proceedings
Volume44
Issue number11
Publication statusPublished - Dec 1 1985

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ASJC Scopus subject areas

  • Medicine(all)

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Devlin, J. J., Widera, G., Mellor, A., Fahrner, K., Sherman, D., Weiss, E. H., & Flavell, R. A. (1985). Evolution and expression of the transplantation antigen gene family. Federation Proceedings, 44(11), 2736-2740.