Evolution of mouse T-box genes by tandem duplication and cluster dispersion

Sergei I. Agulnik, Nancy Garvey, Sarah Hancock, Ilya Ruvinsky, Deborah L. Chapman, Irina Agulnik, Roni Bollag, Virginia Papaioannou, Lee M. Silver

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

The T-box genes comprise an ancient family of putative transcription factors conserved across species as divergent as Mus musculus and Caenorhabditis elegans. All T-box gene products are characterized by a novel 174-186-amino acid DNA binding domain called the T-box that was first discovered in the polypeptide products of the mouse T locus and the Drosophila melanogaster optomotor-blind gene. Earlier studies allowed the identification of five mouse T-box genes, T, Tbx1-3, and Tbr1, that all map to different chromosomal locations and are expressed in unique temporal and spatial patterns during embryogenesis. Here, we report the discovery of three new members of the mouse T-box gene family, names Tbx4, Tbx5, and Tbx6. Two of these newly discovered genes, Tbx4 and Tbx5, were found to be tightly linked to previously identified T-box genes. Combined results from phylogenetic, linkage, and physical mapping studies provide a picture for the evolution of a T-box subfamily by unequal crossing over to form a two-gene cluster that was duplicated and dispersed to two chromosomal locations. This analysis suggests that Tbx4 and Tbx5 are cognate genes that diverged apart from a common ancestral gene during early vertebrate evolution.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalGenetics
Volume144
Issue number1
StatePublished - Sep 14 1996

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Gene Duplication
Multigene Family
Genes
Chromosome Mapping
Caenorhabditis elegans
Drosophila melanogaster
Embryonic Development
Names
Vertebrates
Transcription Factors
Amino Acids
Peptides
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Agulnik, S. I., Garvey, N., Hancock, S., Ruvinsky, I., Chapman, D. L., Agulnik, I., ... Silver, L. M. (1996). Evolution of mouse T-box genes by tandem duplication and cluster dispersion. Genetics, 144(1), 249-254.

Evolution of mouse T-box genes by tandem duplication and cluster dispersion. / Agulnik, Sergei I.; Garvey, Nancy; Hancock, Sarah; Ruvinsky, Ilya; Chapman, Deborah L.; Agulnik, Irina; Bollag, Roni; Papaioannou, Virginia; Silver, Lee M.

In: Genetics, Vol. 144, No. 1, 14.09.1996, p. 249-254.

Research output: Contribution to journalArticle

Agulnik, SI, Garvey, N, Hancock, S, Ruvinsky, I, Chapman, DL, Agulnik, I, Bollag, R, Papaioannou, V & Silver, LM 1996, 'Evolution of mouse T-box genes by tandem duplication and cluster dispersion', Genetics, vol. 144, no. 1, pp. 249-254.
Agulnik SI, Garvey N, Hancock S, Ruvinsky I, Chapman DL, Agulnik I et al. Evolution of mouse T-box genes by tandem duplication and cluster dispersion. Genetics. 1996 Sep 14;144(1):249-254.
Agulnik, Sergei I. ; Garvey, Nancy ; Hancock, Sarah ; Ruvinsky, Ilya ; Chapman, Deborah L. ; Agulnik, Irina ; Bollag, Roni ; Papaioannou, Virginia ; Silver, Lee M. / Evolution of mouse T-box genes by tandem duplication and cluster dispersion. In: Genetics. 1996 ; Vol. 144, No. 1. pp. 249-254.
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