Exercise capacity as an independent risk factor for adverse cardiovascular outcomes among nondiabetic and diabetic patients

Bredy Pierre-Louis, Achuta Kumar Guddati, Muhammed Khyzar Hayat Syed, Vanessa E. Gorospe, Mark Manguerra, Chaitali Bagchi, Wilbert S. Aronow, Chul Ahn

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: To investigate if decreased exercise capacity is an independent risk factor for major adverse cardiovascular events (MACE) in diabetics and nondiabetics. Material and methods: The association of decreased exercise capacity (EC) during a treadmill exercise sestamibi stress test with MACE was investigated in 490 nondiabetics and 404 diabetics. Mean follow-up was 53 months. Results: Nondiabetics with a predicted EC < 85% had a higher prevalence of myocardial ischemia (34% vs. 19%, p = 0.0002), 2- or 3-vessel obstructive coronary artery disease (CAD) (31% vs. 13%, p = 0.016), myocardial infarction (MI) (17% vs. 7%, p = 0.0005), stroke (8% vs. 2%, p = 0.002), death (11% vs. 3%, p = 0.0002), and MI or stroke or death at follow-up (32% vs. 11%, p < 0.001) compared to nondiabetics with a predicted EC . 85%. Diabetics with a predicted EC < 85% had a higher prevalence of myocardial ischemia (48% vs. 32%, p = 0.0009), 2- or 3-vessel obstructive CAD (54% vs. 28%, p = 0.001), MI (32% vs. 14%, p < 0.001), stroke (22% vs. 6%, p < 0.001), death (17% vs. 9%, p = 0.031) , and MI or stroke or death at follow-up (65% vs. 27%, p < 0.001). Stepwise Cox regression analysis showed decreased EC was an independent and significant risk factor for MACE among nondiabetics (hazard ratio 3.3, p < 0.0001) and diabetics (hazard ratio 2.7, p < 0.0001). Conclusions: Diabetics and nondiabetics with decreased EC were at increased risk for MACE with nondiabetics and decreased EC at similar risk as diabetics with normal EC.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalArchives of Medical Science
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2014

Fingerprint

Exercise
Stroke
Myocardial Infarction
Myocardial Ischemia
Coronary Artery Disease
Exercise Test
Regression Analysis

Keywords

  • Diabetes
  • Exercise capacity
  • Major adverse cardiac events

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Exercise capacity as an independent risk factor for adverse cardiovascular outcomes among nondiabetic and diabetic patients. / Pierre-Louis, Bredy; Guddati, Achuta Kumar; Syed, Muhammed Khyzar Hayat; Gorospe, Vanessa E.; Manguerra, Mark; Bagchi, Chaitali; Aronow, Wilbert S.; Ahn, Chul.

In: Archives of Medical Science, Vol. 10, No. 1, 01.02.2014, p. 25-32.

Research output: Contribution to journalArticle

Pierre-Louis, Bredy ; Guddati, Achuta Kumar ; Syed, Muhammed Khyzar Hayat ; Gorospe, Vanessa E. ; Manguerra, Mark ; Bagchi, Chaitali ; Aronow, Wilbert S. ; Ahn, Chul. / Exercise capacity as an independent risk factor for adverse cardiovascular outcomes among nondiabetic and diabetic patients. In: Archives of Medical Science. 2014 ; Vol. 10, No. 1. pp. 25-32.
@article{e90181a87e1644c2ae5cf37474ac7c6d,
title = "Exercise capacity as an independent risk factor for adverse cardiovascular outcomes among nondiabetic and diabetic patients",
abstract = "Introduction: To investigate if decreased exercise capacity is an independent risk factor for major adverse cardiovascular events (MACE) in diabetics and nondiabetics. Material and methods: The association of decreased exercise capacity (EC) during a treadmill exercise sestamibi stress test with MACE was investigated in 490 nondiabetics and 404 diabetics. Mean follow-up was 53 months. Results: Nondiabetics with a predicted EC < 85{\%} had a higher prevalence of myocardial ischemia (34{\%} vs. 19{\%}, p = 0.0002), 2- or 3-vessel obstructive coronary artery disease (CAD) (31{\%} vs. 13{\%}, p = 0.016), myocardial infarction (MI) (17{\%} vs. 7{\%}, p = 0.0005), stroke (8{\%} vs. 2{\%}, p = 0.002), death (11{\%} vs. 3{\%}, p = 0.0002), and MI or stroke or death at follow-up (32{\%} vs. 11{\%}, p < 0.001) compared to nondiabetics with a predicted EC . 85{\%}. Diabetics with a predicted EC < 85{\%} had a higher prevalence of myocardial ischemia (48{\%} vs. 32{\%}, p = 0.0009), 2- or 3-vessel obstructive CAD (54{\%} vs. 28{\%}, p = 0.001), MI (32{\%} vs. 14{\%}, p < 0.001), stroke (22{\%} vs. 6{\%}, p < 0.001), death (17{\%} vs. 9{\%}, p = 0.031) , and MI or stroke or death at follow-up (65{\%} vs. 27{\%}, p < 0.001). Stepwise Cox regression analysis showed decreased EC was an independent and significant risk factor for MACE among nondiabetics (hazard ratio 3.3, p < 0.0001) and diabetics (hazard ratio 2.7, p < 0.0001). Conclusions: Diabetics and nondiabetics with decreased EC were at increased risk for MACE with nondiabetics and decreased EC at similar risk as diabetics with normal EC.",
keywords = "Diabetes, Exercise capacity, Major adverse cardiac events",
author = "Bredy Pierre-Louis and Guddati, {Achuta Kumar} and Syed, {Muhammed Khyzar Hayat} and Gorospe, {Vanessa E.} and Mark Manguerra and Chaitali Bagchi and Aronow, {Wilbert S.} and Chul Ahn",
year = "2014",
month = "2",
day = "1",
doi = "10.5114/aoms.2014.40731",
language = "English (US)",
volume = "10",
pages = "25--32",
journal = "Archives of Medical Science",
issn = "1734-1922",
publisher = "Termedia Publishing House Ltd.",
number = "1",

}

TY - JOUR

T1 - Exercise capacity as an independent risk factor for adverse cardiovascular outcomes among nondiabetic and diabetic patients

AU - Pierre-Louis, Bredy

AU - Guddati, Achuta Kumar

AU - Syed, Muhammed Khyzar Hayat

AU - Gorospe, Vanessa E.

AU - Manguerra, Mark

AU - Bagchi, Chaitali

AU - Aronow, Wilbert S.

AU - Ahn, Chul

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Introduction: To investigate if decreased exercise capacity is an independent risk factor for major adverse cardiovascular events (MACE) in diabetics and nondiabetics. Material and methods: The association of decreased exercise capacity (EC) during a treadmill exercise sestamibi stress test with MACE was investigated in 490 nondiabetics and 404 diabetics. Mean follow-up was 53 months. Results: Nondiabetics with a predicted EC < 85% had a higher prevalence of myocardial ischemia (34% vs. 19%, p = 0.0002), 2- or 3-vessel obstructive coronary artery disease (CAD) (31% vs. 13%, p = 0.016), myocardial infarction (MI) (17% vs. 7%, p = 0.0005), stroke (8% vs. 2%, p = 0.002), death (11% vs. 3%, p = 0.0002), and MI or stroke or death at follow-up (32% vs. 11%, p < 0.001) compared to nondiabetics with a predicted EC . 85%. Diabetics with a predicted EC < 85% had a higher prevalence of myocardial ischemia (48% vs. 32%, p = 0.0009), 2- or 3-vessel obstructive CAD (54% vs. 28%, p = 0.001), MI (32% vs. 14%, p < 0.001), stroke (22% vs. 6%, p < 0.001), death (17% vs. 9%, p = 0.031) , and MI or stroke or death at follow-up (65% vs. 27%, p < 0.001). Stepwise Cox regression analysis showed decreased EC was an independent and significant risk factor for MACE among nondiabetics (hazard ratio 3.3, p < 0.0001) and diabetics (hazard ratio 2.7, p < 0.0001). Conclusions: Diabetics and nondiabetics with decreased EC were at increased risk for MACE with nondiabetics and decreased EC at similar risk as diabetics with normal EC.

AB - Introduction: To investigate if decreased exercise capacity is an independent risk factor for major adverse cardiovascular events (MACE) in diabetics and nondiabetics. Material and methods: The association of decreased exercise capacity (EC) during a treadmill exercise sestamibi stress test with MACE was investigated in 490 nondiabetics and 404 diabetics. Mean follow-up was 53 months. Results: Nondiabetics with a predicted EC < 85% had a higher prevalence of myocardial ischemia (34% vs. 19%, p = 0.0002), 2- or 3-vessel obstructive coronary artery disease (CAD) (31% vs. 13%, p = 0.016), myocardial infarction (MI) (17% vs. 7%, p = 0.0005), stroke (8% vs. 2%, p = 0.002), death (11% vs. 3%, p = 0.0002), and MI or stroke or death at follow-up (32% vs. 11%, p < 0.001) compared to nondiabetics with a predicted EC . 85%. Diabetics with a predicted EC < 85% had a higher prevalence of myocardial ischemia (48% vs. 32%, p = 0.0009), 2- or 3-vessel obstructive CAD (54% vs. 28%, p = 0.001), MI (32% vs. 14%, p < 0.001), stroke (22% vs. 6%, p < 0.001), death (17% vs. 9%, p = 0.031) , and MI or stroke or death at follow-up (65% vs. 27%, p < 0.001). Stepwise Cox regression analysis showed decreased EC was an independent and significant risk factor for MACE among nondiabetics (hazard ratio 3.3, p < 0.0001) and diabetics (hazard ratio 2.7, p < 0.0001). Conclusions: Diabetics and nondiabetics with decreased EC were at increased risk for MACE with nondiabetics and decreased EC at similar risk as diabetics with normal EC.

KW - Diabetes

KW - Exercise capacity

KW - Major adverse cardiac events

UR - http://www.scopus.com/inward/record.url?scp=84900669687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900669687&partnerID=8YFLogxK

U2 - 10.5114/aoms.2014.40731

DO - 10.5114/aoms.2014.40731

M3 - Article

VL - 10

SP - 25

EP - 32

JO - Archives of Medical Science

JF - Archives of Medical Science

SN - 1734-1922

IS - 1

ER -