Exercise dose response in muscle

B. D. Duscha, B. H. Annex, J. L. Johnson, K. Huffman, J. Houmard, W. E. Kraus

Research output: Contribution to journalReview article

Abstract

Exercise increases peak VO 2 partially through muscle adaptations. However, understanding muscle adaptations related to exercise dose is incomplete. This study investigated exercise training dose on capillaries per fiber and capillaries per area; and citrate synthase from vastus lateralis and related both to changes in peak VO 2. This randomized trial compared 3 exercise doses: low amount-moderate intensity (n=40) , low amount-high intensity (n=47), high amount-high intensity (n=41), and a control group (n=35). Both measures of capillary supply increased in all exercise groups (p<0.05). Low amount-high intensity and high amount-high intensity improved citrate synthase (p<0.05) and the low amount-moderate intensity citrate synthase approached significance (p=0.059). Muscle improvements were only related to improvements in peak VO 2 in high amount-high intensity (citrate synthase, r=-0.304; capillaries:fiber, r=-0.318; p<0.05 and capillaries/mm 2 r=-0.310, p<0.05). These data suggest muscle adaptations occur following both low and high exercise doses, but are only related to improved peak VO 2 following high amount-high intensity training.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalInternational Journal of Sports Medicine
Volume33
Issue number3
DOIs
StatePublished - Jan 19 2012
Externally publishedYes

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Citrate (si)-Synthase
Muscles
Quadriceps Muscle
Exercise
Control Groups

Keywords

  • capillary density
  • citrate synthase
  • exercise training
  • muscle adaptations

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Duscha, B. D., Annex, B. H., Johnson, J. L., Huffman, K., Houmard, J., & Kraus, W. E. (2012). Exercise dose response in muscle. International Journal of Sports Medicine, 33(3), 218-223. https://doi.org/10.1055/s-0031-1291323

Exercise dose response in muscle. / Duscha, B. D.; Annex, B. H.; Johnson, J. L.; Huffman, K.; Houmard, J.; Kraus, W. E.

In: International Journal of Sports Medicine, Vol. 33, No. 3, 19.01.2012, p. 218-223.

Research output: Contribution to journalReview article

Duscha, BD, Annex, BH, Johnson, JL, Huffman, K, Houmard, J & Kraus, WE 2012, 'Exercise dose response in muscle', International Journal of Sports Medicine, vol. 33, no. 3, pp. 218-223. https://doi.org/10.1055/s-0031-1291323
Duscha BD, Annex BH, Johnson JL, Huffman K, Houmard J, Kraus WE. Exercise dose response in muscle. International Journal of Sports Medicine. 2012 Jan 19;33(3):218-223. https://doi.org/10.1055/s-0031-1291323
Duscha, B. D. ; Annex, B. H. ; Johnson, J. L. ; Huffman, K. ; Houmard, J. ; Kraus, W. E. / Exercise dose response in muscle. In: International Journal of Sports Medicine. 2012 ; Vol. 33, No. 3. pp. 218-223.
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