Exercise hyperventilation in patients with McArdle's disease

J. M. Hagberg, E. F. Coyle, James Edwin Carroll, J. M. Miller, W. H. Martin, M. H. Brooke

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

This study was undertaken to determine if patients who lack muscle phosphorylase (i.e., McArdle's disease), and therefore the ability to produce lactic acid during exercise, demonstrate a normal hyperventilatory response during progressive incremental exercise. As expected these patients did not increase their blood lactate above resting levels, whereas the blood lactate levels of normal subjects increased 8- to 10-fold during maximal exercise. The venous pH of the normal subjects decreased markedly during exercise that resulted in hyperventilation. The patients demonstrated a distinct increase in ventilation with respect to O2 consumption similar to that seen in normal individuals during submaximal exercise. However their hyperventilation resulted in an increase in pH because there was no underlying metabolic acidosis. Endtidal partial pressures of O2 and CO2 also reflected a distinct hyperventilation in both groups at approximately 70-85% maximal O2 consumption. These data show that hyperventilation occurs during intense exercise, even when there is no increase in plasma [H+]. Since arterial CO2 levels were decreasing and O2 levels were increasing during the hyperventilation, it is possible that nonhumoral stimuli originating in the active muscles in the brain elicit the hyperventilation observed during intense exercise.

Original languageEnglish (US)
Pages (from-to)991-994
Number of pages4
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume52
Issue number4
StatePublished - Oct 25 1982
Externally publishedYes

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Glycogen Storage Disease Type V
Hyperventilation
Exercise
Lactic Acid
Muscles
Phosphorylases
Partial Pressure
Acidosis
Ventilation
Brain

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

Cite this

Hagberg, J. M., Coyle, E. F., Carroll, J. E., Miller, J. M., Martin, W. H., & Brooke, M. H. (1982). Exercise hyperventilation in patients with McArdle's disease. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, 52(4), 991-994.

Exercise hyperventilation in patients with McArdle's disease. / Hagberg, J. M.; Coyle, E. F.; Carroll, James Edwin; Miller, J. M.; Martin, W. H.; Brooke, M. H.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 52, No. 4, 25.10.1982, p. 991-994.

Research output: Contribution to journalArticle

Hagberg, J. M. ; Coyle, E. F. ; Carroll, James Edwin ; Miller, J. M. ; Martin, W. H. ; Brooke, M. H. / Exercise hyperventilation in patients with McArdle's disease. In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 1982 ; Vol. 52, No. 4. pp. 991-994.
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