TY - JOUR
T1 - Exercise testing in patients with cystic fibrosis—importance of ventilatory parameters
AU - Tucker, Matthew A.
AU - Lee, Nichole
AU - Rodriguez-Miguelez, Paula
AU - Looney, Jacob
AU - Crandall, Reva H.
AU - Forseen, Caralee
AU - McKie, Kathleen T.
AU - Harris, Ryan A.
N1 - Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/1/30
Y1 - 2019/1/30
N2 - Background: Ventilatory parameters obtained during exercise predict survival in several chronic diseases; however, long-term changes in exercise ventilatory parameters in patients with cystic fibrosis (CF) have yet to be examined and potential differences between sexes in CF are unknown. Purpose: We sought to examine the change in exercise ventilatory parameters over time in patients with CF and determine if the change is different between sexes. Methods: Exercise capacity (VO 2 peak) and exercise ventilatory parameters (V E /VO 2 peak, V E /VCO 2 peak, and V E /VCO 2 slope) were determined from a maximal cardio-pulmonary test on a cycle ergometer on two visits separated by 39 ± 16 months in 20 patients with CF (10 female, 10 male). Results: No differences between sexes were observed at visit 1 (all p > 0.05). Overall, exercise ventilatory parameters significantly (p < 0.05) deteriorated between visits, with no change (p > 0.05) in VO 2 peak. Moreover, compared to males, female patients exhibited greater deteriorations in V E /VO 2 peak (p = 0.001), V E /VCO 2 peak (p = 0.002), and V E /VCO 2 slope (p = 0.016) between visits. Conclusions: These data in patients with CF indicate that exercise ventilatory parameters decline over time despite no change in VO 2 peak, and female patients exhibit a more rapid deterioration compared to males.
AB - Background: Ventilatory parameters obtained during exercise predict survival in several chronic diseases; however, long-term changes in exercise ventilatory parameters in patients with cystic fibrosis (CF) have yet to be examined and potential differences between sexes in CF are unknown. Purpose: We sought to examine the change in exercise ventilatory parameters over time in patients with CF and determine if the change is different between sexes. Methods: Exercise capacity (VO 2 peak) and exercise ventilatory parameters (V E /VO 2 peak, V E /VCO 2 peak, and V E /VCO 2 slope) were determined from a maximal cardio-pulmonary test on a cycle ergometer on two visits separated by 39 ± 16 months in 20 patients with CF (10 female, 10 male). Results: No differences between sexes were observed at visit 1 (all p > 0.05). Overall, exercise ventilatory parameters significantly (p < 0.05) deteriorated between visits, with no change (p > 0.05) in VO 2 peak. Moreover, compared to males, female patients exhibited greater deteriorations in V E /VO 2 peak (p = 0.001), V E /VCO 2 peak (p = 0.002), and V E /VCO 2 slope (p = 0.016) between visits. Conclusions: These data in patients with CF indicate that exercise ventilatory parameters decline over time despite no change in VO 2 peak, and female patients exhibit a more rapid deterioration compared to males.
KW - Exercise capacity
KW - Pulmonary function
KW - Ventilatory efficiency
UR - http://www.scopus.com/inward/record.url?scp=85055716846&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055716846&partnerID=8YFLogxK
U2 - 10.1007/s00421-018-4018-5
DO - 10.1007/s00421-018-4018-5
M3 - Article
C2 - 30357514
AN - SCOPUS:85055716846
SN - 1439-6319
VL - 119
SP - 227
EP - 234
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 1
ER -
