Exercise testing in patients with cystic fibrosis—importance of ventilatory parameters

Matthew A. Tucker, Nichole Lee, Paula Rodriguez-Miguelez, Jacob Looney, Reva H. Crandall, Caralee Johnson Forseen, Kathleen T McKie, Ryan A. Harris

Research output: Contribution to journalArticle

Abstract

Background: Ventilatory parameters obtained during exercise predict survival in several chronic diseases; however, long-term changes in exercise ventilatory parameters in patients with cystic fibrosis (CF) have yet to be examined and potential differences between sexes in CF are unknown. Purpose: We sought to examine the change in exercise ventilatory parameters over time in patients with CF and determine if the change is different between sexes. Methods: Exercise capacity (VO 2 peak) and exercise ventilatory parameters (V E /VO 2 peak, V E /VCO 2 peak, and V E /VCO 2 slope) were determined from a maximal cardio-pulmonary test on a cycle ergometer on two visits separated by 39 ± 16 months in 20 patients with CF (10 female, 10 male). Results: No differences between sexes were observed at visit 1 (all p > 0.05). Overall, exercise ventilatory parameters significantly (p < 0.05) deteriorated between visits, with no change (p > 0.05) in VO 2 peak. Moreover, compared to males, female patients exhibited greater deteriorations in V E /VO 2 peak (p = 0.001), V E /VCO 2 peak (p = 0.002), and V E /VCO 2 slope (p = 0.016) between visits. Conclusions: These data in patients with CF indicate that exercise ventilatory parameters decline over time despite no change in VO 2 peak, and female patients exhibit a more rapid deterioration compared to males.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalEuropean Journal of Applied Physiology
Volume119
Issue number1
DOIs
StatePublished - Jan 30 2019

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Exercise
Cystic Fibrosis
Sex Characteristics
Chronic Disease
Lung
Survival

Keywords

  • Exercise capacity
  • Pulmonary function
  • Ventilatory efficiency

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

Cite this

Exercise testing in patients with cystic fibrosis—importance of ventilatory parameters. / Tucker, Matthew A.; Lee, Nichole; Rodriguez-Miguelez, Paula; Looney, Jacob; Crandall, Reva H.; Forseen, Caralee Johnson; McKie, Kathleen T; Harris, Ryan A.

In: European Journal of Applied Physiology, Vol. 119, No. 1, 30.01.2019, p. 227-234.

Research output: Contribution to journalArticle

Tucker, Matthew A. ; Lee, Nichole ; Rodriguez-Miguelez, Paula ; Looney, Jacob ; Crandall, Reva H. ; Forseen, Caralee Johnson ; McKie, Kathleen T ; Harris, Ryan A. / Exercise testing in patients with cystic fibrosis—importance of ventilatory parameters. In: European Journal of Applied Physiology. 2019 ; Vol. 119, No. 1. pp. 227-234.
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