Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus

Keshia Jackson, Helaine M. Vieira Silva, Wenfeng Zhang, Lisete C. Michelini, Javier Eduardo Stern

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Oxytocinergic and vasopressinergic brain stem projections have been shown to play an important role in mediating cardiovascular adjustments during exercise training (ET). The aim of the present work was to determine whether the intrinsic excitability of hypothalamic neurons giving rise to brain stem peptidergic projections is altered as a consequence of ET. Whole cell patch-clamp recordings were obtained from nucleus of the solitarii tract (NTS)-projecting paraventricular nucleus of the hypothalamus (PVN) neurons and from supraoptic nucleus (SON) and PVN magnocellular cells (MNCs), in hypothalamic slices obtained from sedentary (S) and ET rats. Our results indicate that intrinsic excitability of PVN neurons that innervate the NTS (PVN-NTS) is enhanced by ET, resulting in a more efficient input-output function (increase number of evoked actions potentials, steeper frequency/current relationships and slower decaying frequency/time relationships). Changes in input-output function were accompanied by smaller hyperpolarizing afterpotentials (HAPs) and afterhyperpolarizing potentials (AHPs), during and after trains of spikes, respectively. On the other hand, a decreased efficacy in the input-output function was observed in SON/PVN MNCs during ET. Altogether, our results indicate that ET differentially affects the intrinsic excitability of autonomic and neurosecretory SON and PVN neurons. Increased excitability in PVN-NTS neurons may contribute to enhanced release of OT and VP peptides in the dorsal brain stem, and cardiovascular fine-tuning during exercise training.

Original languageEnglish (US)
Pages (from-to)3211-3220
Number of pages10
JournalJournal of Neurophysiology
Volume94
Issue number5
DOIs
StatePublished - Nov 1 2005

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Paraventricular Hypothalamic Nucleus
Hypothalamus
Exercise
Neurons
Supraoptic Nucleus
Brain Stem
Solitary Nucleus
Evoked Potentials
Action Potentials
Peptides

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus. / Jackson, Keshia; Vieira Silva, Helaine M.; Zhang, Wenfeng; Michelini, Lisete C.; Stern, Javier Eduardo.

In: Journal of Neurophysiology, Vol. 94, No. 5, 01.11.2005, p. 3211-3220.

Research output: Contribution to journalArticle

Jackson, Keshia ; Vieira Silva, Helaine M. ; Zhang, Wenfeng ; Michelini, Lisete C. ; Stern, Javier Eduardo. / Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus. In: Journal of Neurophysiology. 2005 ; Vol. 94, No. 5. pp. 3211-3220.
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