Exosomes for Bone Diseases

Paulomi Sanghavi, Porter Young, Sunil Upadhyay, Mark W Hamrick

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The bone marrow microenvironment contains a variety of cell types. These cells interact in complex ways to mediate cell differentiation, proliferation, and cell death, and cell-cell communication plays a key role in these interactions throughout growth, development, aging, and disease. Exosomes and microvesicles (MVs) derived from bone marrow cells are now recognized to play important roles in cell-cell communication, and these extracellular vesicles are found to contain a variety of microRNAs. Certain of these miRNAs can impact tumor angiogenesis in bone and others can influence cancer metastasis to bone. Current efforts are exploring the possibilities and methods of how MVs can be used to deliver genetic and pharmacologic therapy to specific target tissues. Future research into this exciting area of cell biology is likely to yield important insights that have significant clinical and therapeutic impact.

Original languageEnglish (US)
Title of host publicationMesenchymal Stem Cell Derived Exosomes
Subtitle of host publicationThe Potential for Translational Nanomedicine
PublisherElsevier Inc.
Pages1-15
Number of pages15
ISBN (Electronic)9780128004975
ISBN (Print)9780128001646
DOIs
Publication statusPublished - Jan 1 2015

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Keywords

  • Aging
  • Bone marrow microenvironment
  • Bone metabolism
  • Cell-cell communication

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sanghavi, P., Young, P., Upadhyay, S., & Hamrick, M. W. (2015). Exosomes for Bone Diseases. In Mesenchymal Stem Cell Derived Exosomes: The Potential for Translational Nanomedicine (pp. 1-15). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800164-6.00010-1