Exosomes for Bone Diseases

Paulomi Sanghavi; Porter Young; Sunil Upadhyay; Mark W Hamrick

doi:10.1016/B978-0-12-800164-6.00010-1

Exosomes for Bone Diseases

Paulomi Sanghavi, Porter Young, Sunil Upadhyay, Mark W Hamrick

Cellular Biology and Anatomy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The bone marrow microenvironment contains a variety of cell types. These cells interact in complex ways to mediate cell differentiation, proliferation, and cell death, and cell-cell communication plays a key role in these interactions throughout growth, development, aging, and disease. Exosomes and microvesicles (MVs) derived from bone marrow cells are now recognized to play important roles in cell-cell communication, and these extracellular vesicles are found to contain a variety of microRNAs. Certain of these miRNAs can impact tumor angiogenesis in bone and others can influence cancer metastasis to bone. Current efforts are exploring the possibilities and methods of how MVs can be used to deliver genetic and pharmacologic therapy to specific target tissues. Future research into this exciting area of cell biology is likely to yield important insights that have significant clinical and therapeutic impact.

Original language	English (US)
Title of host publication	Mesenchymal Stem Cell Derived Exosomes
Subtitle of host publication	The Potential for Translational Nanomedicine
Publisher	Elsevier Inc.
Pages	1-15
Number of pages	15
ISBN (Electronic)	9780128004975
ISBN (Print)	9780128001646
DOIs	https://doi.org/10.1016/B978-0-12-800164-6.00010-1
State	Published - Jan 1 2015

Keywords

Aging
Bone marrow microenvironment
Bone metabolism
Cell-cell communication

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-800164-6.00010-1

Cite this

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abstract = "The bone marrow microenvironment contains a variety of cell types. These cells interact in complex ways to mediate cell differentiation, proliferation, and cell death, and cell-cell communication plays a key role in these interactions throughout growth, development, aging, and disease. Exosomes and microvesicles (MVs) derived from bone marrow cells are now recognized to play important roles in cell-cell communication, and these extracellular vesicles are found to contain a variety of microRNAs. Certain of these miRNAs can impact tumor angiogenesis in bone and others can influence cancer metastasis to bone. Current efforts are exploring the possibilities and methods of how MVs can be used to deliver genetic and pharmacologic therapy to specific target tissues. Future research into this exciting area of cell biology is likely to yield important insights that have significant clinical and therapeutic impact.",

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AU - Upadhyay, Sunil

AU - Hamrick, Mark W

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N2 - The bone marrow microenvironment contains a variety of cell types. These cells interact in complex ways to mediate cell differentiation, proliferation, and cell death, and cell-cell communication plays a key role in these interactions throughout growth, development, aging, and disease. Exosomes and microvesicles (MVs) derived from bone marrow cells are now recognized to play important roles in cell-cell communication, and these extracellular vesicles are found to contain a variety of microRNAs. Certain of these miRNAs can impact tumor angiogenesis in bone and others can influence cancer metastasis to bone. Current efforts are exploring the possibilities and methods of how MVs can be used to deliver genetic and pharmacologic therapy to specific target tissues. Future research into this exciting area of cell biology is likely to yield important insights that have significant clinical and therapeutic impact.

AB - The bone marrow microenvironment contains a variety of cell types. These cells interact in complex ways to mediate cell differentiation, proliferation, and cell death, and cell-cell communication plays a key role in these interactions throughout growth, development, aging, and disease. Exosomes and microvesicles (MVs) derived from bone marrow cells are now recognized to play important roles in cell-cell communication, and these extracellular vesicles are found to contain a variety of microRNAs. Certain of these miRNAs can impact tumor angiogenesis in bone and others can influence cancer metastasis to bone. Current efforts are exploring the possibilities and methods of how MVs can be used to deliver genetic and pharmacologic therapy to specific target tissues. Future research into this exciting area of cell biology is likely to yield important insights that have significant clinical and therapeutic impact.

KW - Aging

KW - Bone marrow microenvironment

KW - Bone metabolism

KW - Cell-cell communication

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Exosomes for Bone Diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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