Expanded Expression of Toll-Like Receptor 2 in Proliferative Verrucous Leukoplakia

Joon Koh, Zoya B. Kurago

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Proliferative verrucous leukoplakia (PVL) is a premalignant condition of the oral mucosa with > 70% chance of progression to squamous cell carcinoma (SCC), while lacking the common risks and behavior seen in non-PVL oral squamous carcinogenesis. PVL follows a multi-stage slow, relentless and usually multifocal expansion of surface epithelial thickening that over time takes on a verrucous architecture, eventually leading to verrucous carcinoma and/or dysplasia followed by “conventional” SCC, a process that takes years and is notoriously difficult to manage. As mucosal surfaces and carcinomas arising at these sites, are colonized by microorganisms, host receptors for microbial products have received attention as potential contributors to carcinogenesis. Studies show that microbial pattern recognition toll-like receptor (TLR)2 in various epithelial cells is upregulated in premalignant lesions and in malignant cells and can activate oncogenic pathways. Because of the highly progressive nature of PVL, we examined TLR2 expression in well-characterized PVL samples by immunohistochemistry. We found that, similar to epithelial dysplasia and SCC, PVL keratinocytes throughout the epithelial thickness showed diffuse TLR2 expression even in early stage lesions prior to onset of dysplasia. In contrast, oral mucosal samples in the absence of hyperorothokeratosis or dysplasia, expressed TLR2 primarily in the basal and parabasal layers. Given the high rates of PVL transformation and the previously established pro-cancer role of high TLR2 expression in malignant oral squamous cells, it is important to determine how its’ expression and functions are regulated in the oral squamous epithelium, and what is the specific TLR2 role in carcinogenesis.

Original languageEnglish (US)
Pages (from-to)635-642
Number of pages8
JournalHead and Neck Pathology
Volume13
Issue number4
DOIs
StatePublished - Dec 1 2019

Keywords

  • Oral cancer
  • PVL
  • Proliferative verrucous leukoplakia
  • Squamous cell carcinoma
  • Squamous epithelium
  • TLR2
  • Toll-like receptor 2
  • Verrucous hyperplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

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