Experimental aortocoronary saphenous vein graft function after mechanical cardiac massage with the Anstadt Cup

Mark P. Anstadt, R. A. Perez-Tamayo, Mark G. Davies, Per Otto Hagen, James S. St-Louis, Steven C. Hendrickson, Salah Abdel-Aleem, Keith A. Reimer, George L. Anstadt, James E. Lowe

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Direct mechanical ventricular actuation (DMVA) using the Anstadt Cup can achieve total circulatory support by massaging the fibrillating, asystolic, or failing heart. The device does not contact the blood or cause significant myocardial trauma. The purpose of this study was to assess the functional integrity of saphenous vein grafts (SVGs) subjected to DMVA vs cardiopulmonary bypass (CPB). Human SVGs were used to bypass the ligated left anterior descending coronary artery in 11 dogs. Animals then received 2 hrs of either DMVA (n = 5) or CPB (n = 6) during sustained ventricular fibrillation. Grafted and non grafted (control) SVG segments were then studied in vitro. SVG patency was confirmed by radiolabeled microspheres and pathologic evaluation. Matched SVG specimens (control) were not exposed to circulatory support. All SVGs were subjected to isometric tension studies. SVG contractile responses to norepinephrine, bradykinin, serotonin, and histamine were assessed. Maximal response to all agonists were similar between control SVG segments compared to either CPB or DMVA support (p = NS, ANOVA). All cumulative dose response curves were similar after DMVA vs CPB support. In conclusion, the smooth muscle function of SVGs in this study was not significantly altered by DMVA support. Therefore, short-term DMVA support does not impair patency or adversely effect the functional integrity of smooth muscle within SVGs.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalASAIO Journal
Volume42
Issue number4
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Experimental aortocoronary saphenous vein graft function after mechanical cardiac massage with the Anstadt Cup'. Together they form a unique fingerprint.

Cite this