Experimental Peri-Implant Tissue Breakdown Around Hydroxyapatite-Coated Implants

Oliver Hanisch, Carlo Alberto Cortella, Milos M. Boskovic, Robert A. James, Jørgen Slots, Ulf M E Wikesjö

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

This study monitored experimental peri-implant tissue breakdown around hydroxyapatite (HA)-coated titanium dental implants. Thirty-two HA-coated cylindrical implants, in groups of two, were bilaterally inserted in the posterior maxilla and mandible in 4 Macaco mulatta monkeys. Two months after healing-abutment connection, a 2-month plaque control program was initiated. Clinical and radiographic recordings and peri-implant submucosal microbial samples were then obtained (baseline). Cotton ligatures were next placed around the healing-abutments and plaque control measures were abandoned. Clinical and radiographic recordings were repeated at 5 and 10 months post-baseline. Microbial samples were repeated at 10 months post-baseline, and ligatures were removed. Clinical, radiographic, and microbial examinations were again repeated at 11 months post-baseline. Mean modified plaque index (mPI; P < 0.01), gingival index (GI; P < 0.01), and bleeding on probing (BOP; P < 0.05) scores increased over the plaque accumulation period. The mPI, and GI scores decreased after ligature removal (P < 0.001). Mean probing depth (PD) and clinical attachment level (AL) increased between baseline and the 5- and 10-month examinations (ΔPD 3.0 mm; ΔAL 2.7 mm; P < 0.05). PD values were reduced following ligature removal (P < 0.05). AL values and BP scores remained unchanged. A significant negative correlation was found between induced defect depth and width of keratinized mucosa at baseline (P = 0.03). At baseline, the submucosal microbiota was dominated by coccoid cells. Following ligature placement, the microbiota included a large proportion of Gram-negative anaerobic rods, predominantly Porphyromonas gingivalis, Bacteroides forsythus, and Fusobacterium species as well as beta-hemolytic streptococci. Ligature removal had a limited effect on the composition of the submucosal microbiota. This non-human primate study indicates that ligature-enhanced plaque accumulation is a precursor of progressive peri-implant tissue breakdown around HA-coated implants. The associated microbiota resembles that of peri-implantitis and destructive periodontal disease in humans. This preclinical model may be useful to study modalities aimed at arresting peri-implant tissue breakdown and at regeneration of bone in peri-implantitis defects.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalJournal of periodontology
Volume68
Issue number1
DOIs
StatePublished - Jan 1 1997

Fingerprint

Experimental Implants
Durapatite
Ligation
Microbiota
Peri-Implantitis
Fusobacterium
Periodontal Index
Porphyromonas gingivalis
Bone Regeneration
Dental Implants
Maxilla
Periodontal Diseases
Streptococcus
Titanium
Mandible
Primates
Haplorhini
Mucous Membrane
Hemorrhage

Keywords

  • Animal studies
  • Dental implants
  • Hydroxyapatite
  • Periodontal diseases/pathogenesis
  • Titanium

ASJC Scopus subject areas

  • Periodontics

Cite this

Hanisch, O., Cortella, C. A., Boskovic, M. M., James, R. A., Slots, J., & Wikesjö, U. M. E. (1997). Experimental Peri-Implant Tissue Breakdown Around Hydroxyapatite-Coated Implants. Journal of periodontology, 68(1), 59-66. https://doi.org/10.1902/jop.1997.68.1.59

Experimental Peri-Implant Tissue Breakdown Around Hydroxyapatite-Coated Implants. / Hanisch, Oliver; Cortella, Carlo Alberto; Boskovic, Milos M.; James, Robert A.; Slots, Jørgen; Wikesjö, Ulf M E.

In: Journal of periodontology, Vol. 68, No. 1, 01.01.1997, p. 59-66.

Research output: Contribution to journalArticle

Hanisch, O, Cortella, CA, Boskovic, MM, James, RA, Slots, J & Wikesjö, UME 1997, 'Experimental Peri-Implant Tissue Breakdown Around Hydroxyapatite-Coated Implants', Journal of periodontology, vol. 68, no. 1, pp. 59-66. https://doi.org/10.1902/jop.1997.68.1.59
Hanisch O, Cortella CA, Boskovic MM, James RA, Slots J, Wikesjö UME. Experimental Peri-Implant Tissue Breakdown Around Hydroxyapatite-Coated Implants. Journal of periodontology. 1997 Jan 1;68(1):59-66. https://doi.org/10.1902/jop.1997.68.1.59
Hanisch, Oliver ; Cortella, Carlo Alberto ; Boskovic, Milos M. ; James, Robert A. ; Slots, Jørgen ; Wikesjö, Ulf M E. / Experimental Peri-Implant Tissue Breakdown Around Hydroxyapatite-Coated Implants. In: Journal of periodontology. 1997 ; Vol. 68, No. 1. pp. 59-66.
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