Experimental prostatitis in nonhuman primates: II. Ascending acute prostatitis

Durwood Earnest Neal, J. Patrick Dilworth, M. Bernice Kaack, Peter Didier, James A. Roberts

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Bacterial prostatitis is a common cause of urinary tract infection in males, but little is known of its pathophysiology. To study this, we developed a nonhuman primate model using a wild‐type clinical isolate of Escherichia coli. Primates have a prostatic anatomy that is similar to humans, which makes them ideal as an animal model of this disease. The monkeys had a urethral inoculation of this organism and were then followed with urine, blood, and semen cultures, white blood counts, and renal scans. They were sacrificed at from 10 days to 4 weeks, and their genitourinary tracts histologically examined. The prostatitis paralleled that reported in humans, and we conclude that the infection occurs by the ascending route. The organisms causing the infection in man do so in our primate model, and the histologic change is also the same. Thus, the primate model holds promise for studies to help us understand this disease.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalThe Prostate
Volume17
Issue number3
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Prostatitis
Primates
Animal Disease Models
Infection
Semen
Urinary Tract Infections
Haplorhini
Anatomy
Urine
Escherichia coli
Kidney

Keywords

  • P‐fimbriated E. coli
  • animal model
  • ascending infection

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Experimental prostatitis in nonhuman primates : II. Ascending acute prostatitis. / Neal, Durwood Earnest; Dilworth, J. Patrick; Kaack, M. Bernice; Didier, Peter; Roberts, James A.

In: The Prostate, Vol. 17, No. 3, 01.01.1990, p. 233-239.

Research output: Contribution to journalArticle

Neal, DE, Dilworth, JP, Kaack, MB, Didier, P & Roberts, JA 1990, 'Experimental prostatitis in nonhuman primates: II. Ascending acute prostatitis', The Prostate, vol. 17, no. 3, pp. 233-239. https://doi.org/10.1002/pros.2990170307
Neal, Durwood Earnest ; Dilworth, J. Patrick ; Kaack, M. Bernice ; Didier, Peter ; Roberts, James A. / Experimental prostatitis in nonhuman primates : II. Ascending acute prostatitis. In: The Prostate. 1990 ; Vol. 17, No. 3. pp. 233-239.
@article{bd58601b33c34f6c9abd502bda148b96,
title = "Experimental prostatitis in nonhuman primates: II. Ascending acute prostatitis",
abstract = "Bacterial prostatitis is a common cause of urinary tract infection in males, but little is known of its pathophysiology. To study this, we developed a nonhuman primate model using a wild‐type clinical isolate of Escherichia coli. Primates have a prostatic anatomy that is similar to humans, which makes them ideal as an animal model of this disease. The monkeys had a urethral inoculation of this organism and were then followed with urine, blood, and semen cultures, white blood counts, and renal scans. They were sacrificed at from 10 days to 4 weeks, and their genitourinary tracts histologically examined. The prostatitis paralleled that reported in humans, and we conclude that the infection occurs by the ascending route. The organisms causing the infection in man do so in our primate model, and the histologic change is also the same. Thus, the primate model holds promise for studies to help us understand this disease.",
keywords = "P‐fimbriated E. coli, animal model, ascending infection",
author = "Neal, {Durwood Earnest} and Dilworth, {J. Patrick} and Kaack, {M. Bernice} and Peter Didier and Roberts, {James A.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1002/pros.2990170307",
language = "English (US)",
volume = "17",
pages = "233--239",
journal = "Prostate",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Experimental prostatitis in nonhuman primates

T2 - II. Ascending acute prostatitis

AU - Neal, Durwood Earnest

AU - Dilworth, J. Patrick

AU - Kaack, M. Bernice

AU - Didier, Peter

AU - Roberts, James A.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Bacterial prostatitis is a common cause of urinary tract infection in males, but little is known of its pathophysiology. To study this, we developed a nonhuman primate model using a wild‐type clinical isolate of Escherichia coli. Primates have a prostatic anatomy that is similar to humans, which makes them ideal as an animal model of this disease. The monkeys had a urethral inoculation of this organism and were then followed with urine, blood, and semen cultures, white blood counts, and renal scans. They were sacrificed at from 10 days to 4 weeks, and their genitourinary tracts histologically examined. The prostatitis paralleled that reported in humans, and we conclude that the infection occurs by the ascending route. The organisms causing the infection in man do so in our primate model, and the histologic change is also the same. Thus, the primate model holds promise for studies to help us understand this disease.

AB - Bacterial prostatitis is a common cause of urinary tract infection in males, but little is known of its pathophysiology. To study this, we developed a nonhuman primate model using a wild‐type clinical isolate of Escherichia coli. Primates have a prostatic anatomy that is similar to humans, which makes them ideal as an animal model of this disease. The monkeys had a urethral inoculation of this organism and were then followed with urine, blood, and semen cultures, white blood counts, and renal scans. They were sacrificed at from 10 days to 4 weeks, and their genitourinary tracts histologically examined. The prostatitis paralleled that reported in humans, and we conclude that the infection occurs by the ascending route. The organisms causing the infection in man do so in our primate model, and the histologic change is also the same. Thus, the primate model holds promise for studies to help us understand this disease.

KW - P‐fimbriated E. coli

KW - animal model

KW - ascending infection

UR - http://www.scopus.com/inward/record.url?scp=0025672737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025672737&partnerID=8YFLogxK

U2 - 10.1002/pros.2990170307

DO - 10.1002/pros.2990170307

M3 - Article

C2 - 2235731

AN - SCOPUS:0025672737

VL - 17

SP - 233

EP - 239

JO - Prostate

JF - Prostate

SN - 0270-4137

IS - 3

ER -