Exploiting plug-and-play electrochemistry for drug discovery

Lixia Gao, Yong Teng

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Electrochemistry has emerged as a powerful analytical technique for chemical analysis of living cells, biologically active molecules and metabolites. Electrochemical biosensor, microfluidics and mass spectrometry are the most frequently used methods for electrochemical detection and monitory, which comprise a collection of extremely useful measurement tools for various fields of biology and medicine. Most recently, electrochemistry has been shown to be coupled with nanotechnology and genetic engineering to generate new enabling technologies, providing rapid, selective, and sensitive detection and diagnosis platforms. The primary focus of this review is to highlight the utility of electrochemical strategies and their conjunction with other approaches for drug metabolism and discovery. Current challenges and possible future developments and applications of electrochemistry in drug studies are also discussed.

Original languageEnglish (US)
Pages (from-to)567-577
Number of pages11
JournalFuture Medicinal Chemistry
Volume8
Issue number5
DOIs
StatePublished - Apr 2016

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Keywords

  • drug discovery
  • drug metabolism
  • electrochemical biosensor
  • electrochemical mass spectrometry
  • electrochemical microfluidics
  • electrochemistry

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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