Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder: Preliminary findings of altered neurosteroid levels

Nagy A. Youssef, Daniel W. Bradford, Jason D. Kilts, Steven T. Szabo, Jennifer C. Naylor, Trina B. Allen, Jennifer L. Strauss, Robert M. Hamer, Mira Brunca, Lawrence J. Shampine, Christine E. Marx

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Clozapine and lithium increase neurosteroids in rodents, and both drugs demonstrate antisuicidal actions. We therefore hypothesized that neurosteroid levels may be reduced in patients with schizophrenia or bipolar disorder who completed suicide. Aims: To investigate neurosteroid levels in the parietal cortex and posterior cingulate in schizophrenia and bipolar patients who died by suicide, and compare them with patients with these disorders who died of other causes. Method: Neurosteroid levels were quantified by gas chromatography/mass spectrometry in the parietal cortex and posterior cingulate. Mann-Whitney analyses were conducted in exploratory post hoc analyses to investigate neurosteroids as possible biomarker candidates for suicide. Results: The study showed that pregnenolone was significantly decreased in the parietal cortex in the combined group of patients with schizophrenia or bipolar disorder who died by suicide (n = 13) compared with patients with these disorders who died of other causes (n = 17, p =.02). Pregnenolone levels were also lower in the parietal cortex in the individual group of schizophrenia patients who died by suicide (n = 4) compared with schizophrenia patients who died of other causes (n = 11) p =.04). Conclusion: Pregnenolone alterations may be relevant to the neurobiology of suicide in schizophrenia and bipolar disorder.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalCrisis
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Bipolar Disorder
Suicide
Neurotransmitter Agents
Schizophrenia
Biomarkers
Parietal Lobe
Pregnenolone
Gyrus Cinguli
Neurobiology
Clozapine
Lithium
Gas Chromatography-Mass Spectrometry
Rodentia
Pharmaceutical Preparations

Keywords

  • Bipolar disorder
  • Neurosteroid
  • Parietal cortex
  • Pregnenolone
  • Schizophrenia
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder : Preliminary findings of altered neurosteroid levels. / Youssef, Nagy A.; Bradford, Daniel W.; Kilts, Jason D.; Szabo, Steven T.; Naylor, Jennifer C.; Allen, Trina B.; Strauss, Jennifer L.; Hamer, Robert M.; Brunca, Mira; Shampine, Lawrence J.; Marx, Christine E.

In: Crisis, Vol. 36, No. 1, 01.01.2015, p. 46-54.

Research output: Contribution to journalArticle

Youssef, NA, Bradford, DW, Kilts, JD, Szabo, ST, Naylor, JC, Allen, TB, Strauss, JL, Hamer, RM, Brunca, M, Shampine, LJ & Marx, CE 2015, 'Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder: Preliminary findings of altered neurosteroid levels', Crisis, vol. 36, no. 1, pp. 46-54. https://doi.org/10.1027/0227-5910/a000280
Youssef, Nagy A. ; Bradford, Daniel W. ; Kilts, Jason D. ; Szabo, Steven T. ; Naylor, Jennifer C. ; Allen, Trina B. ; Strauss, Jennifer L. ; Hamer, Robert M. ; Brunca, Mira ; Shampine, Lawrence J. ; Marx, Christine E. / Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder : Preliminary findings of altered neurosteroid levels. In: Crisis. 2015 ; Vol. 36, No. 1. pp. 46-54.
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