Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort

Christine L.M. Joseph, Edward M. Zoratti, Dennis Randall Ownby, Suzanne Havstad, Charlotte Nicholas, Christian Nageotte, Rana Misiak, Robert Enberg, Jerel Ezell, Christine Cole Johnson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Suspected food allergies are the cause of more than 200,000 visits to the emergency department annually. Racial differences in the prevalence of food allergy have also been reported, but the evidence is less conclusive. Researchers continue to struggle with the identification of food allergy for epidemiologic studies. Objective To explore racial differences in IgE-mediated food allergy (IgE-FA) in a birth cohort. Methods We used a panel of board-certified allergists to systematically identify IgE-FA to egg, milk, or peanut in a multiethnic birth cohort in which patient medical history, patient symptoms, and clinical data were available through 36 months of age. Results Of the 590 infants analyzed, 52.9% were male and 65.8% African American. Sensitization (serum specific IgE >0.35 IU/mL) to the food allergens was significantly higher for African American children compared with non-African American children as has been previously reported. No statistically significant racial/ethnic differences in IgE-FA were observed; however, a higher proportion of African American children were designated as having peanut allergy, and the percentage of African American children with an IgE level greater than 95% predictive decision points for peanut was 1.7% vs 0.5% for non-African American children. With the use of logistic regression, race/ethnicity was not significantly associated with IgE-FA (adjusted odds ratio, 1.12; 95% confidence interval, 0.58-2.17; P =.75) but was associated with sensitization to more than 1 of the food allergens (adjusted odds ratio, 1.80; 95% confidence interval, 1.22-2.65; P =.003). Conclusion We did not observe an elevated risk of IgE-FA for African American children, although established differences in sensitization were observed. Racial/ethnic differences in sensitization must be taken into consideration when investigating disparities in asthma and allergy.

Original languageEnglish (US)
Pages (from-to)219-224.e1
JournalAnnals of Allergy, Asthma and Immunology
Volume116
Issue number3
DOIs
StatePublished - Mar 1 2016

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Food Hypersensitivity
Immunoglobulin E
Parturition
African Americans
Allergens
Peanut Hypersensitivity
Odds Ratio
Confidence Intervals
Food
Ovum
Hospital Emergency Service
Epidemiologic Studies
Hypersensitivity
Milk
Asthma
Logistic Models
Research Personnel
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Joseph, C. L. M., Zoratti, E. M., Ownby, D. R., Havstad, S., Nicholas, C., Nageotte, C., ... Johnson, C. C. (2016). Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort. Annals of Allergy, Asthma and Immunology, 116(3), 219-224.e1. https://doi.org/10.1016/j.anai.2015.12.019

Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort. / Joseph, Christine L.M.; Zoratti, Edward M.; Ownby, Dennis Randall; Havstad, Suzanne; Nicholas, Charlotte; Nageotte, Christian; Misiak, Rana; Enberg, Robert; Ezell, Jerel; Johnson, Christine Cole.

In: Annals of Allergy, Asthma and Immunology, Vol. 116, No. 3, 01.03.2016, p. 219-224.e1.

Research output: Contribution to journalArticle

Joseph, CLM, Zoratti, EM, Ownby, DR, Havstad, S, Nicholas, C, Nageotte, C, Misiak, R, Enberg, R, Ezell, J & Johnson, CC 2016, 'Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort', Annals of Allergy, Asthma and Immunology, vol. 116, no. 3, pp. 219-224.e1. https://doi.org/10.1016/j.anai.2015.12.019
Joseph, Christine L.M. ; Zoratti, Edward M. ; Ownby, Dennis Randall ; Havstad, Suzanne ; Nicholas, Charlotte ; Nageotte, Christian ; Misiak, Rana ; Enberg, Robert ; Ezell, Jerel ; Johnson, Christine Cole. / Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort. In: Annals of Allergy, Asthma and Immunology. 2016 ; Vol. 116, No. 3. pp. 219-224.e1.
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abstract = "Background Suspected food allergies are the cause of more than 200,000 visits to the emergency department annually. Racial differences in the prevalence of food allergy have also been reported, but the evidence is less conclusive. Researchers continue to struggle with the identification of food allergy for epidemiologic studies. Objective To explore racial differences in IgE-mediated food allergy (IgE-FA) in a birth cohort. Methods We used a panel of board-certified allergists to systematically identify IgE-FA to egg, milk, or peanut in a multiethnic birth cohort in which patient medical history, patient symptoms, and clinical data were available through 36 months of age. Results Of the 590 infants analyzed, 52.9{\%} were male and 65.8{\%} African American. Sensitization (serum specific IgE >0.35 IU/mL) to the food allergens was significantly higher for African American children compared with non-African American children as has been previously reported. No statistically significant racial/ethnic differences in IgE-FA were observed; however, a higher proportion of African American children were designated as having peanut allergy, and the percentage of African American children with an IgE level greater than 95{\%} predictive decision points for peanut was 1.7{\%} vs 0.5{\%} for non-African American children. With the use of logistic regression, race/ethnicity was not significantly associated with IgE-FA (adjusted odds ratio, 1.12; 95{\%} confidence interval, 0.58-2.17; P =.75) but was associated with sensitization to more than 1 of the food allergens (adjusted odds ratio, 1.80; 95{\%} confidence interval, 1.22-2.65; P =.003). Conclusion We did not observe an elevated risk of IgE-FA for African American children, although established differences in sensitization were observed. Racial/ethnic differences in sensitization must be taken into consideration when investigating disparities in asthma and allergy.",
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