Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells

Juan Wu; Anatolij Horuzsko

doi:10.1016/j.humimm.2009.01.024

Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells

Juan Wu, Anatolij Horuzsko

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The expression of inhibitory immunoglobulin-like transcripts (ILTs) on dendritic cells (DCs) is a biomarker of tolerogenic DCs. In this article we discuss current knowledge on the function of ILTs and explore the molecular mechanisms involved in modulation of DCs via the inhibitory receptor and its natural ligand, rendering these cells tolerogenic. We propose a method to enhance targeting of inhibitory receptors on DCs using microparticles containing a preferential ligand, HLA-G, and monoclonal antibody against the pan-DCs marker CD11c. The double-coated microparticles increase the binding of ILT4 receptor and improve modulation of DCs in vitro and in vivo. This targeting concept can be used for regulation of specific immune responses to antigens in transplantation, autoimmunity, allergy, and cancer.

Original language	English (US)
Pages (from-to)	353-356
Number of pages	4
Journal	Human Immunology
Volume	70
Issue number	5
DOIs	https://doi.org/10.1016/j.humimm.2009.01.024
State	Published - May 2009

Keywords

Dendritic cells
Immunotherapy
Inhibitory receptors
Tolerance
Transplantation

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.humimm.2009.01.024

Cite this

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title = "Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells",

abstract = "The expression of inhibitory immunoglobulin-like transcripts (ILTs) on dendritic cells (DCs) is a biomarker of tolerogenic DCs. In this article we discuss current knowledge on the function of ILTs and explore the molecular mechanisms involved in modulation of DCs via the inhibitory receptor and its natural ligand, rendering these cells tolerogenic. We propose a method to enhance targeting of inhibitory receptors on DCs using microparticles containing a preferential ligand, HLA-G, and monoclonal antibody against the pan-DCs marker CD11c. The double-coated microparticles increase the binding of ILT4 receptor and improve modulation of DCs in vitro and in vivo. This targeting concept can be used for regulation of specific immune responses to antigens in transplantation, autoimmunity, allergy, and cancer.",

keywords = "Dendritic cells, Immunotherapy, Inhibitory receptors, Tolerance, Transplantation",

author = "Juan Wu and Anatolij Horuzsko",

note = "Funding Information: Disclosure statement: A.H. has patents pending on HLA-G. The authors are grateful to Dr. Rhea-Beth Markowitz for critical reading of the manuscript. This work is supported in parts by grants from the National Institutes of Health and the Roche Organ Transplantation Foundations.",

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T1 - Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells

AU - Wu, Juan

AU - Horuzsko, Anatolij

N1 - Funding Information: Disclosure statement: A.H. has patents pending on HLA-G. The authors are grateful to Dr. Rhea-Beth Markowitz for critical reading of the manuscript. This work is supported in parts by grants from the National Institutes of Health and the Roche Organ Transplantation Foundations.

PY - 2009/5

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N2 - The expression of inhibitory immunoglobulin-like transcripts (ILTs) on dendritic cells (DCs) is a biomarker of tolerogenic DCs. In this article we discuss current knowledge on the function of ILTs and explore the molecular mechanisms involved in modulation of DCs via the inhibitory receptor and its natural ligand, rendering these cells tolerogenic. We propose a method to enhance targeting of inhibitory receptors on DCs using microparticles containing a preferential ligand, HLA-G, and monoclonal antibody against the pan-DCs marker CD11c. The double-coated microparticles increase the binding of ILT4 receptor and improve modulation of DCs in vitro and in vivo. This targeting concept can be used for regulation of specific immune responses to antigens in transplantation, autoimmunity, allergy, and cancer.

AB - The expression of inhibitory immunoglobulin-like transcripts (ILTs) on dendritic cells (DCs) is a biomarker of tolerogenic DCs. In this article we discuss current knowledge on the function of ILTs and explore the molecular mechanisms involved in modulation of DCs via the inhibitory receptor and its natural ligand, rendering these cells tolerogenic. We propose a method to enhance targeting of inhibitory receptors on DCs using microparticles containing a preferential ligand, HLA-G, and monoclonal antibody against the pan-DCs marker CD11c. The double-coated microparticles increase the binding of ILT4 receptor and improve modulation of DCs in vitro and in vivo. This targeting concept can be used for regulation of specific immune responses to antigens in transplantation, autoimmunity, allergy, and cancer.

KW - Dendritic cells

KW - Immunotherapy

KW - Inhibitory receptors

KW - Tolerance

KW - Transplantation

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Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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