Expression and function of iron-regulatory proteins in retina

Jaya Pranava Gnana-Prakasam, Pamela Moore Martin, Sylvia B Smith, Vadivel Ganapathy

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Iron is essential for cell survival and function; yet excess iron is toxic to cells. Therefore, the cellular and whole-body levels of iron are regulated exquisitely. At least a dozen proteins participate in the regulation of iron homeostasis. Hemochromatosis, a genetic disorder of iron overload, is caused by mutations in at least five genes, namely HFE, hemojuvelin, Transferrin receptor 2, ferroportin, and hepcidin. Retina is separated from systemic circulation by inner and outer blood-retinal barriers; therefore it is widely believed that this tissue is immune to changes in systemic circulation. Even though hemochromatosis is associated with iron overload and dysfunction of a variety of systemic organs, little is known on the effects of this disease on the retina. Recent studies have shown that all five genes that are associated with hemochromatosis are expressed in the retina in a cell type-specific manner. The retinal pigment epithelium, which forms the outer blood-retinal barrier, expresses all of these five genes. It is therefore clearly evident that iron homeostasis in the retina is maintained locally by active participation of various iron-regulatory proteins. Excess iron is detrimental to the retina as evidenced from human studies and from mouse models of iron overload. Retinal iron homeostasis is disrupted in various clinical conditions such as hemochromatosis, aceruloplasminemia, age-related macular degeneration, and bacterial and viral infections.

Original languageEnglish (US)
Pages (from-to)363-370
Number of pages8
JournalIUBMB Life
Volume62
Issue number5
DOIs
StatePublished - May 1 2010

Fingerprint

Iron-Regulatory Proteins
Retina
Iron
Hemochromatosis
Iron Overload
Blood-Retinal Barrier
Homeostasis
Genes
Hepcidins
Inborn Genetic Diseases
Transferrin Receptors
Retinal Pigment Epithelium
Poisons
Blood
Macular Degeneration
Virus Diseases
Bacterial Infections
Cell Survival
Retinal Pigments
Mutation

Keywords

  • Age-related macular degeneration
  • Hemochromatosis
  • Iron toxicity
  • Oxidative damage
  • Retina

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Expression and function of iron-regulatory proteins in retina. / Gnana-Prakasam, Jaya Pranava; Martin, Pamela Moore; Smith, Sylvia B; Ganapathy, Vadivel.

In: IUBMB Life, Vol. 62, No. 5, 01.05.2010, p. 363-370.

Research output: Contribution to journalReview article

Gnana-Prakasam, Jaya Pranava ; Martin, Pamela Moore ; Smith, Sylvia B ; Ganapathy, Vadivel. / Expression and function of iron-regulatory proteins in retina. In: IUBMB Life. 2010 ; Vol. 62, No. 5. pp. 363-370.
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