Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice

A. L. Mellor, P. D. Tomlinson, J. Antoniou, P. Chandler, P. Robinson, M. Felstein, J. Sloan, A. Edwards, L. O'Reilly, A. Cooke, E. Simpson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Qa-2 molecules are weak transplantation antigens encoded by class I genes of the major histocompatibility complex. When expressed In transgenic CBA mice, Qa-2 molecules provoke rapid rejection of skin grafts and strong, Qa-2 specific, cytotoxic T-cell responses. Efficient rejection of skin grafts from Qa-2 transgenic mice takes place when Qa-2 molecules are attached to the cell membrane with a glycophosphatidyl anchor or by a transmembrane protein domain, except that rejection times are siightiy longer In the former case. These results demonstrate that Qa-2 molecules can behave as major transplantation antigens, as do closely related H-2 molecules. Failure of Qa-2 molecules to provoke strong T-cell responses in non-transgenic mice Is probably due to the very low level of expression of Qa-2 molecules In skin kératinocytes from such mice since these cells express increased levels of Qa-2 molecules In all Qa-2 transgenic mice.

Original languageEnglish (US)
Pages (from-to)493-502
Number of pages10
JournalInternational Immunology
Volume3
Issue number5
DOIs
StatePublished - Jan 1 1991

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Major Histocompatibility Complex
Transgenic Mice
Histocompatibility Antigens
Graft Rejection
Skin
MHC Class I Genes
T-Lymphocytes
Inbred CBA Mouse
Cell Membrane

Keywords

  • Major histocompatibility complex
  • Transgenic mice

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Mellor, A. L., Tomlinson, P. D., Antoniou, J., Chandler, P., Robinson, P., Felstein, M., ... Simpson, E. (1991). Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice. International Immunology, 3(5), 493-502. https://doi.org/10.1093/intimm/3.5.493

Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice. / Mellor, A. L.; Tomlinson, P. D.; Antoniou, J.; Chandler, P.; Robinson, P.; Felstein, M.; Sloan, J.; Edwards, A.; O'Reilly, L.; Cooke, A.; Simpson, E.

In: International Immunology, Vol. 3, No. 5, 01.01.1991, p. 493-502.

Research output: Contribution to journalArticle

Mellor, AL, Tomlinson, PD, Antoniou, J, Chandler, P, Robinson, P, Felstein, M, Sloan, J, Edwards, A, O'Reilly, L, Cooke, A & Simpson, E 1991, 'Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice', International Immunology, vol. 3, no. 5, pp. 493-502. https://doi.org/10.1093/intimm/3.5.493
Mellor, A. L. ; Tomlinson, P. D. ; Antoniou, J. ; Chandler, P. ; Robinson, P. ; Felstein, M. ; Sloan, J. ; Edwards, A. ; O'Reilly, L. ; Cooke, A. ; Simpson, E. / Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice. In: International Immunology. 1991 ; Vol. 3, No. 5. pp. 493-502.
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