Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice

A. L. Mellor, P. D. Tomlinson, J. Antoniou, P. Chandler, P. Robinson, M. Felstein, J. Sloan, A. Edwards, L. O'Reilly, A. Cooke, E. Simpson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Qa-2 molecules are weak transplantation antigens encoded by class I genes of the major histocompatibility complex. When expressed In transgenic CBA mice, Qa-2 molecules provoke rapid rejection of skin grafts and strong, Qa-2 specific, cytotoxic T-cell responses. Efficient rejection of skin grafts from Qa-2 transgenic mice takes place when Qa-2 molecules are attached to the cell membrane with a glycophosphatidyl anchor or by a transmembrane protein domain, except that rejection times are siightiy longer In the former case. These results demonstrate that Qa-2 molecules can behave as major transplantation antigens, as do closely related H-2 molecules. Failure of Qa-2 molecules to provoke strong T-cell responses in non-transgenic mice Is probably due to the very low level of expression of Qa-2 molecules In skin kératinocytes from such mice since these cells express increased levels of Qa-2 molecules In all Qa-2 transgenic mice.

Original languageEnglish (US)
Pages (from-to)493-502
Number of pages10
JournalInternational Immunology
Volume3
Issue number5
DOIs
StatePublished - May 1991

Keywords

  • Major histocompatibility complex
  • Transgenic mice

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice'. Together they form a unique fingerprint.

  • Cite this

    Mellor, A. L., Tomlinson, P. D., Antoniou, J., Chandler, P., Robinson, P., Felstein, M., Sloan, J., Edwards, A., O'Reilly, L., Cooke, A., & Simpson, E. (1991). Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice. International Immunology, 3(5), 493-502. https://doi.org/10.1093/intimm/3.5.493