Expression of BAG-1 in invasive breast carcinomas

Shou Ching Tang, Nadine Shaheta, Garry Chernenko, Mohmoud Khalifa, Xikui Wang

Research output: Contribution to journalArticle

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Abstract

Purpose: The purpose of this study was to retrospectively evaluate the expression of BAG-1 in invasive breast carcinomas. The intensity and subcellular distribution of BAG-1 expression was correlated with conventional prognostic factors and with disease-free and overall survival. Patients and Methods: One hundred forty patients diagnosed with invasive breast cancer in St. John's, Newfoundland, between 1986 and 1996 were included in the study. The median follow-up of the study was 8 years. Expression of BAG-1 was determined by immunohistochemical staining of paraffin-embedded breast tumor tissues. Results: Of the 140 breast carcinomas examined, 77.1% were positive for BAG-1 expression. Except for differentiation, no correlation was observed between BAG-1 expression and conventional prognostic factors such as age, histology, stage, and estrogen and progesterone receptor status. In multivariate analysis, BAG-1 expression was significantly associated with shorter disease-free (P = .0052) and overall survival (P = .0033). Patients whose tumors expressed nuclear BAG-1 tended to have a shorter disease-free (63 v 84 months; P = 0.4493) and overall (69 v 99 months, P = .1009) survival. Conclusion: BAG-1 is overexpressed in the majority of invasive breast carcinomas. Although BAG-1 did not correlate with conventional prognostic factors, its overexpression, especially the nuclear expression, may be associated with a shorter disease-free and overall survival. Our preliminary data strongly indicate that further investigation is warranted to define the role of BAG-1 as an independent prognostic factor in patients with newly diagnosed breast cancer.

Original languageEnglish (US)
Pages (from-to)1710-1719
Number of pages10
JournalJournal of Clinical Oncology
Volume17
Issue number6
StatePublished - Jun 1 1999

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Breast Neoplasms
Disease-Free Survival
Newfoundland and Labrador
Survival
Progesterone Receptors
Estrogen Receptors
Paraffin
Histology
Multivariate Analysis
Staining and Labeling
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tang, S. C., Shaheta, N., Chernenko, G., Khalifa, M., & Wang, X. (1999). Expression of BAG-1 in invasive breast carcinomas. Journal of Clinical Oncology, 17(6), 1710-1719.

Expression of BAG-1 in invasive breast carcinomas. / Tang, Shou Ching; Shaheta, Nadine; Chernenko, Garry; Khalifa, Mohmoud; Wang, Xikui.

In: Journal of Clinical Oncology, Vol. 17, No. 6, 01.06.1999, p. 1710-1719.

Research output: Contribution to journalArticle

Tang, SC, Shaheta, N, Chernenko, G, Khalifa, M & Wang, X 1999, 'Expression of BAG-1 in invasive breast carcinomas', Journal of Clinical Oncology, vol. 17, no. 6, pp. 1710-1719.
Tang SC, Shaheta N, Chernenko G, Khalifa M, Wang X. Expression of BAG-1 in invasive breast carcinomas. Journal of Clinical Oncology. 1999 Jun 1;17(6):1710-1719.
Tang, Shou Ching ; Shaheta, Nadine ; Chernenko, Garry ; Khalifa, Mohmoud ; Wang, Xikui. / Expression of BAG-1 in invasive breast carcinomas. In: Journal of Clinical Oncology. 1999 ; Vol. 17, No. 6. pp. 1710-1719.
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abstract = "Purpose: The purpose of this study was to retrospectively evaluate the expression of BAG-1 in invasive breast carcinomas. The intensity and subcellular distribution of BAG-1 expression was correlated with conventional prognostic factors and with disease-free and overall survival. Patients and Methods: One hundred forty patients diagnosed with invasive breast cancer in St. John's, Newfoundland, between 1986 and 1996 were included in the study. The median follow-up of the study was 8 years. Expression of BAG-1 was determined by immunohistochemical staining of paraffin-embedded breast tumor tissues. Results: Of the 140 breast carcinomas examined, 77.1{\%} were positive for BAG-1 expression. Except for differentiation, no correlation was observed between BAG-1 expression and conventional prognostic factors such as age, histology, stage, and estrogen and progesterone receptor status. In multivariate analysis, BAG-1 expression was significantly associated with shorter disease-free (P = .0052) and overall survival (P = .0033). Patients whose tumors expressed nuclear BAG-1 tended to have a shorter disease-free (63 v 84 months; P = 0.4493) and overall (69 v 99 months, P = .1009) survival. Conclusion: BAG-1 is overexpressed in the majority of invasive breast carcinomas. Although BAG-1 did not correlate with conventional prognostic factors, its overexpression, especially the nuclear expression, may be associated with a shorter disease-free and overall survival. Our preliminary data strongly indicate that further investigation is warranted to define the role of BAG-1 as an independent prognostic factor in patients with newly diagnosed breast cancer.",
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N2 - Purpose: The purpose of this study was to retrospectively evaluate the expression of BAG-1 in invasive breast carcinomas. The intensity and subcellular distribution of BAG-1 expression was correlated with conventional prognostic factors and with disease-free and overall survival. Patients and Methods: One hundred forty patients diagnosed with invasive breast cancer in St. John's, Newfoundland, between 1986 and 1996 were included in the study. The median follow-up of the study was 8 years. Expression of BAG-1 was determined by immunohistochemical staining of paraffin-embedded breast tumor tissues. Results: Of the 140 breast carcinomas examined, 77.1% were positive for BAG-1 expression. Except for differentiation, no correlation was observed between BAG-1 expression and conventional prognostic factors such as age, histology, stage, and estrogen and progesterone receptor status. In multivariate analysis, BAG-1 expression was significantly associated with shorter disease-free (P = .0052) and overall survival (P = .0033). Patients whose tumors expressed nuclear BAG-1 tended to have a shorter disease-free (63 v 84 months; P = 0.4493) and overall (69 v 99 months, P = .1009) survival. Conclusion: BAG-1 is overexpressed in the majority of invasive breast carcinomas. Although BAG-1 did not correlate with conventional prognostic factors, its overexpression, especially the nuclear expression, may be associated with a shorter disease-free and overall survival. Our preliminary data strongly indicate that further investigation is warranted to define the role of BAG-1 as an independent prognostic factor in patients with newly diagnosed breast cancer.

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