Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis

Valentyna I. Fesenkova, Anita I. Kurchenko, Maria Luisa Castellani, Pio Conti, Antonia Anogeianaki, Auro Caraffa, Dimitris Kalogeromitros

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.

Original languageEnglish (US)
Pages (from-to)487-498
Number of pages12
JournalImmunopharmacology and Immunotoxicology
Volume29
Issue number3-4
DOIs
StatePublished - Jul 1 2007

Keywords

  • Atopic Dermatitis
  • CD1a
  • CD80
  • CD86
  • Dendritic cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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    Fesenkova, V. I., Kurchenko, A. I., Castellani, M. L., Conti, P., Anogeianaki, A., Caraffa, A., & Kalogeromitros, D. (2007). Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis. Immunopharmacology and Immunotoxicology, 29(3-4), 487-498. https://doi.org/10.1080/08923970701675101