Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis

Valentyna I. Fesenkova; Anita I. Kurchenko; Maria Luisa Castellani; Pio Conti; Antonia Anogeianaki; Auro Caraffa; Dimitris Kalogeromitros

doi:10.1080/08923970701675101

Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis

Valentyna I. Fesenkova, Anita I. Kurchenko, Maria Luisa Castellani, Pio Conti, Antonia Anogeianaki, Auro Caraffa, Dimitris Kalogeromitros

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.

Original language	English (US)
Pages (from-to)	487-498
Number of pages	12
Journal	Immunopharmacology and Immunotoxicology
Volume	29
Issue number	3-4
DOIs	https://doi.org/10.1080/08923970701675101
State	Published - Jul 2007
Externally published	Yes

Keywords

Atopic Dermatitis
CD1a
CD80
CD86
Dendritic cell

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Toxicology
Pharmacology

Access to Document

10.1080/08923970701675101

Cite this

@article{3b9c2655c3e94e4d998438b002b91e23,

title = "Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis",

abstract = "Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.",

keywords = "Atopic Dermatitis, CD1a, CD80, CD86, Dendritic cell",

author = "Fesenkova, {Valentyna I.} and Kurchenko, {Anita I.} and Castellani, {Maria Luisa} and Pio Conti and Antonia Anogeianaki and Auro Caraffa and Dimitris Kalogeromitros",

year = "2007",

month = jul,

doi = "10.1080/08923970701675101",

language = "English (US)",

volume = "29",

pages = "487--498",

journal = "Immunopharmacology and Immunotoxicology",

issn = "0892-3973",

publisher = "Informa Healthcare",

number = "3-4",

}

TY - JOUR

T1 - Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis

AU - Fesenkova, Valentyna I.

AU - Kurchenko, Anita I.

AU - Castellani, Maria Luisa

AU - Conti, Pio

AU - Anogeianaki, Antonia

AU - Caraffa, Auro

AU - Kalogeromitros, Dimitris

PY - 2007/7

Y1 - 2007/7

N2 - Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.

AB - Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.

KW - Atopic Dermatitis

KW - CD1a

KW - CD80

KW - CD86

KW - Dendritic cell

UR - http://www.scopus.com/inward/record.url?scp=37149003666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37149003666&partnerID=8YFLogxK

U2 - 10.1080/08923970701675101

DO - 10.1080/08923970701675101

M3 - Article

C2 - 18075860

AN - SCOPUS:37149003666

SN - 0892-3973

VL - 29

SP - 487

EP - 498

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 3-4

ER -

Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this