Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease

Alfonso Dueñas-Gonzalez, Carlos M. Isales, María Del Mar Abad-Hernandez, Rogelio Gonzalez-Sarmiento, Omar Sangueza, José Rodriguez-Commes

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Breast cancer is characterized by its ability to metastasize rapidly. Factors that might facilitate this metastatic potential include tumor vascularity. Nitric oxide (NO), a labile compound synthesized by NO synthase (NOS), is a major regulator not only of physiologic vascular tone but also of the abnormal vascularity associated with many tumors. To test whether NOS is expressed in primary breast tumors and whether its expression is associated with the presence of metastasis, we analyzed the expression of the inducible NOS in 22 primary breast tumors, and to investigate its association to other gene products related to the metastatic ability of tumor cells, we correlated the expression of the inducible NOS with the expression of the nm23 protein (the product of the putative antimetastatic gene nm23). We found a very strong correlation between the presence of NOS and axillary lymph node metastasis and between NOS and the absence of nm23 protein. These data suggest that NO synthesis and the resulting increase in blood flow to the tumor play a role in the facilitation of tumor metastasis.

Original languageEnglish (US)
Pages (from-to)645-649
Number of pages5
JournalModern Pathology
Volume10
Issue number7
StatePublished - Jul 1 1997

Fingerprint

Nitric Oxide Synthase Type II
Nitric Oxide Synthase
Breast Neoplasms
Neoplasms
Neoplasm Metastasis
Nitric Oxide
Genes
Blood Vessels
Proteins
Lymph Nodes

Keywords

  • Breast cancer
  • Metastasis
  • Nitric oxide synthase
  • nm23

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Dueñas-Gonzalez, A., Isales, C. M., Del Mar Abad-Hernandez, M., Gonzalez-Sarmiento, R., Sangueza, O., & Rodriguez-Commes, J. (1997). Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease. Modern Pathology, 10(7), 645-649.

Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease. / Dueñas-Gonzalez, Alfonso; Isales, Carlos M.; Del Mar Abad-Hernandez, María; Gonzalez-Sarmiento, Rogelio; Sangueza, Omar; Rodriguez-Commes, José.

In: Modern Pathology, Vol. 10, No. 7, 01.07.1997, p. 645-649.

Research output: Contribution to journalArticle

Dueñas-Gonzalez, A, Isales, CM, Del Mar Abad-Hernandez, M, Gonzalez-Sarmiento, R, Sangueza, O & Rodriguez-Commes, J 1997, 'Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease', Modern Pathology, vol. 10, no. 7, pp. 645-649.
Dueñas-Gonzalez A, Isales CM, Del Mar Abad-Hernandez M, Gonzalez-Sarmiento R, Sangueza O, Rodriguez-Commes J. Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease. Modern Pathology. 1997 Jul 1;10(7):645-649.
Dueñas-Gonzalez, Alfonso ; Isales, Carlos M. ; Del Mar Abad-Hernandez, María ; Gonzalez-Sarmiento, Rogelio ; Sangueza, Omar ; Rodriguez-Commes, José. / Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease. In: Modern Pathology. 1997 ; Vol. 10, No. 7. pp. 645-649.
@article{f211d4d8c5df41ddaa6e77a3832b3793,
title = "Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease",
abstract = "Breast cancer is characterized by its ability to metastasize rapidly. Factors that might facilitate this metastatic potential include tumor vascularity. Nitric oxide (NO), a labile compound synthesized by NO synthase (NOS), is a major regulator not only of physiologic vascular tone but also of the abnormal vascularity associated with many tumors. To test whether NOS is expressed in primary breast tumors and whether its expression is associated with the presence of metastasis, we analyzed the expression of the inducible NOS in 22 primary breast tumors, and to investigate its association to other gene products related to the metastatic ability of tumor cells, we correlated the expression of the inducible NOS with the expression of the nm23 protein (the product of the putative antimetastatic gene nm23). We found a very strong correlation between the presence of NOS and axillary lymph node metastasis and between NOS and the absence of nm23 protein. These data suggest that NO synthesis and the resulting increase in blood flow to the tumor play a role in the facilitation of tumor metastasis.",
keywords = "Breast cancer, Metastasis, Nitric oxide synthase, nm23",
author = "Alfonso Due{\~n}as-Gonzalez and Isales, {Carlos M.} and {Del Mar Abad-Hernandez}, Mar{\'i}a and Rogelio Gonzalez-Sarmiento and Omar Sangueza and Jos{\'e} Rodriguez-Commes",
year = "1997",
month = "7",
day = "1",
language = "English (US)",
volume = "10",
pages = "645--649",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease

AU - Dueñas-Gonzalez, Alfonso

AU - Isales, Carlos M.

AU - Del Mar Abad-Hernandez, María

AU - Gonzalez-Sarmiento, Rogelio

AU - Sangueza, Omar

AU - Rodriguez-Commes, José

PY - 1997/7/1

Y1 - 1997/7/1

N2 - Breast cancer is characterized by its ability to metastasize rapidly. Factors that might facilitate this metastatic potential include tumor vascularity. Nitric oxide (NO), a labile compound synthesized by NO synthase (NOS), is a major regulator not only of physiologic vascular tone but also of the abnormal vascularity associated with many tumors. To test whether NOS is expressed in primary breast tumors and whether its expression is associated with the presence of metastasis, we analyzed the expression of the inducible NOS in 22 primary breast tumors, and to investigate its association to other gene products related to the metastatic ability of tumor cells, we correlated the expression of the inducible NOS with the expression of the nm23 protein (the product of the putative antimetastatic gene nm23). We found a very strong correlation between the presence of NOS and axillary lymph node metastasis and between NOS and the absence of nm23 protein. These data suggest that NO synthesis and the resulting increase in blood flow to the tumor play a role in the facilitation of tumor metastasis.

AB - Breast cancer is characterized by its ability to metastasize rapidly. Factors that might facilitate this metastatic potential include tumor vascularity. Nitric oxide (NO), a labile compound synthesized by NO synthase (NOS), is a major regulator not only of physiologic vascular tone but also of the abnormal vascularity associated with many tumors. To test whether NOS is expressed in primary breast tumors and whether its expression is associated with the presence of metastasis, we analyzed the expression of the inducible NOS in 22 primary breast tumors, and to investigate its association to other gene products related to the metastatic ability of tumor cells, we correlated the expression of the inducible NOS with the expression of the nm23 protein (the product of the putative antimetastatic gene nm23). We found a very strong correlation between the presence of NOS and axillary lymph node metastasis and between NOS and the absence of nm23 protein. These data suggest that NO synthesis and the resulting increase in blood flow to the tumor play a role in the facilitation of tumor metastasis.

KW - Breast cancer

KW - Metastasis

KW - Nitric oxide synthase

KW - nm23

UR - http://www.scopus.com/inward/record.url?scp=0342894681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0342894681&partnerID=8YFLogxK

M3 - Article

C2 - 9237172

AN - SCOPUS:0342894681

VL - 10

SP - 645

EP - 649

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 7

ER -